一种研究神经肌肉阻滞剂对麻醉猫声带运动的药效学特征的方法。
A method for studying the pharmacodynamic profile of neuromuscular blocking agents on vocal cord movements in anaesthetized cats.
作者信息
Vandenbrom R H, Houwertjes M C, Agoston S
机构信息
Research Group for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen, The Netherlands.
出版信息
Br J Pharmacol. 1991 Apr;102(4):861-4. doi: 10.1111/j.1476-5381.1991.tb12267.x.
Abstract
- A new in vivo experimental method is described whereby the neuromuscular blocking effects of muscle relaxants can be investigated on the intrinsic laryngeal muscles of anaesthetized cats. The peripheral tibialis anterior muscle preparation is employed in the same animal to compare the blocking effect on both preparations. 2. The intrinsic laryngeal muscles react with different sensitivities to the neuromuscular blocking agents when compared to the tibialis anterior muscle. 3. The neuromuscular response in both muscle preparations is similar with steroidal agents but appeared to be different after suxamethonium or isoquinoline analogues. 4. It is concluded that this preparation may become a useful tool for studying new muscle relaxants developed to facilitate rapid intubation conditions.
摘要
- 本文描述了一种新的体内实验方法，通过该方法可以研究肌肉松弛剂对麻醉猫喉内肌的神经肌肉阻滞作用。在同一只动物身上使用胫前肌外周制备物，以比较对两种制备物的阻滞效果。2. 与胫前肌相比，喉内肌对神经肌肉阻滞剂的反应敏感性不同。3. 两种肌肉制备物对甾体类药物的神经肌肉反应相似，但在琥珀胆碱或异喹啉类似物作用后似乎有所不同。4. 得出的结论是，这种制备物可能成为研究为促进快速插管条件而开发的新型肌肉松弛剂的有用工具。
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