三环类抗抑郁药与非霍奇金淋巴瘤
Tricyclic antidepressants and non-Hodgkin lymphoma.
作者信息
Dalton Susanne Oksbjerg, Poulsen Aslak Harbo, Nørgaard Mette, McLaughlin Joseph K, Johansen Christoffer, Friis Søren
机构信息
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
出版信息
Epidemiology. 2008 Jul;19(4):546-9. doi: 10.1097/EDE.0b013e318176bf98.
BACKGROUND
An increased risk of non-Hodgkin lymphoma (NHL) has been reported among long-term users of tricyclic antidepressants.
METHODS
The incidence of NHL among 43,932 users of any antidepressant medication (2 or more prescriptions) in the county of North Jutland, Denmark, during 1989-2003 was compared with NHL incidence in all those not using antidepressants (0 or 1 prescription). We used Poisson regression analysis adjusted for age, sex, period, use of immunosuppressive drugs, corticosteroids, or nonsteroidal anti-inflammatory drugs.
RESULTS
Use of tricyclic antidepressants was associated with an overall increased incidence of NHL (adjusted incidence rate ratio [IRR] = 1.53; 95% confidence interval [CI] = 1.06-2.21) compared with nonuse. The IRR in users with > or =10 prescriptions and 5 or more years of follow-up was 2.50 (CI = 1.43-4.34). Users of other types of antidepressants were not at increased risk of NHL.
CONCLUSIONS
Our results indicate an increased risk of non-Hodgkin lymphoma specifically among long-term users of tricyclic antidepressant medications.
背景
据报道，长期使用三环类抗抑郁药的人群中非霍奇金淋巴瘤（NHL）风险增加。
方法
比较了1989年至2003年丹麦北日德兰郡43932名使用任何抗抑郁药物（2张或更多处方）的患者的NHL发病率与所有未使用抗抑郁药物（0张或1张处方）的患者的NHL发病率。我们使用泊松回归分析，并对年龄、性别、时间段、免疫抑制药物、皮质类固醇或非甾体抗炎药的使用情况进行了校正。
结果
与未使用三环类抗抑郁药相比，使用三环类抗抑郁药与NHL总体发病率增加相关（校正发病率比[IRR]=1.53；95%置信区间[CI]=1.06-2.21）。处方数≥10张且随访5年或更长时间的使用者的IRR为2.50（CI=1.43-4.34）。其他类型抗抑郁药的使用者患NHL的风险并未增加。
结论
我们的结果表明，非霍奇金淋巴瘤风险增加，尤其是在三环类抗抑郁药的长期使用者中。
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