非霍奇金淋巴瘤的风险与非甾体抗炎药的使用

Risk of non-Hodgkin lymphoma and use of non-steroidal anti-inflammatory drugs.

作者信息

Zhang Yuqing, Coogan Patricia F, Palmer Julie R, Strom Brian L, Rosenberg Lynn

机构信息

Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA.

出版信息

Cancer Detect Prev. 2006;30(1):99-101. doi: 10.1016/j.cdp.2005.12.002. Epub 2006 Feb 21.

DOI:10.1016/j.cdp.2005.12.002

PMID:16495019

Abstract

BACKGROUND

Risk factors for non-Hodgkin lymphoma (NHL) are largely unknown. Several studies have examined the relation of non-steroidal anti-inflammatory drug (NSAID) use to the risk of NHL, with inconsistent results.

METHODS

We examined NSAID use among 529 newly diagnosed NHL cases and 2013 controls interviewed from 1977 to 2002 in our Case-Control Surveillance Study.

RESULTS

The odds ratio for NHL among subjects whose regular NSAID use began at least one year prior to hospital admission compared to never users was 0.9 (95% confidence interval (CI): 0.6-1.3). Odds ratios for less than five years, five to less than 10 years, and 10 or more years of regular use were 1.2 (95% CI: 0.8-1.9), 1.0 (95% CI: 0.5-2.1), and 0.4 (95% CI: 0.1-1.0), respectively. The results were similar for regular aspirin use.

CONCLUSION

Our results add to the body of data suggesting that NSAIDs do not increase the risk of NHL and even suggest the possibility of protection by long-term use.

摘要

背景

非霍奇金淋巴瘤（NHL）的危险因素大多未知。几项研究探讨了非甾体抗炎药（NSAID）的使用与NHL风险之间的关系，但结果并不一致。

方法

在我们的病例对照监测研究中，我们调查了1977年至2002年期间接受访谈的529例新诊断的NHL病例和2013例对照者中NSAID的使用情况。

结果

与从未使用过NSAID的受试者相比，在入院前至少一年开始规律使用NSAID的受试者患NHL的比值比为0.9（95%置信区间（CI）：0.6 - 1.3）。规律使用时间少于五年、五至不到十年以及十年或更长时间的比值比分别为1.2（95%CI：0.8 - 1.9）、1.0（95%CI：0.5 - 2.1）和0.4（95%CI：0.1 - 1.0）。规律使用阿司匹林的结果相似。