Lutter Michael, Sakata Ichiro, Osborne-Lawrence Sherri, Rovinsky Sherry A, Anderson Jason G, Jung Saendy, Birnbaum Shari, Yanagisawa Masashi, Elmquist Joel K, Nestler Eric J, Zigman Jeffrey M
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9077, USA.
Nat Neurosci. 2008 Jul;11(7):752-3. doi: 10.1038/nn.2139. Epub 2008 Jun 15.
We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.
我们发现,通过皮下注射或热量限制来提高胃饥饿素水平,会在高架十字迷宫和强迫游泳试验中产生抗焦虑和抗抑郁样反应。此外,慢性社会挫败应激作为一种抑郁症的啮齿动物模型,会持续提高胃饥饿素水平,而生长激素促分泌素受体(Ghsr)基因敲除小鼠在慢性挫败中表现出更严重的有害影响。这些研究结果共同证明了胃饥饿素在抵御慢性应激所致抑郁样症状方面具有此前未知的功能。