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The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.
Nat Neurosci. 2008 Jul;11(7):752-3. doi: 10.1038/nn.2139. Epub 2008 Jun 15.
2
Acute But Not Chronic Calorie Restriction Defends against Stress-Related Anxiety and Despair in a GHS-R1a-Dependent Manner.
Neuroscience. 2019 Aug 1;412:94-104. doi: 10.1016/j.neuroscience.2019.05.067. Epub 2019 Jun 8.
3
Ghrelin alleviates anxiety- and depression-like behaviors induced by chronic unpredictable mild stress in rodents.
Behav Brain Res. 2017 May 30;326:33-43. doi: 10.1016/j.bbr.2017.02.040. Epub 2017 Feb 27.
4
Orexin signaling mediates the antidepressant-like effect of calorie restriction.
J Neurosci. 2008 Mar 19;28(12):3071-5. doi: 10.1523/JNEUROSCI.5584-07.2008.
6
Anxiolytic-Like Effects of Increased Ghrelin Receptor Signaling in the Amygdala.
Int J Neuropsychopharmacol. 2016 Apr 29;19(5). doi: 10.1093/ijnp/pyv123. Print 2016 May.
7
Ghrelin/GHS-R1a signaling plays different roles in anxiety-related behaviors after acute and chronic caloric restriction.
Biochem Biophys Res Commun. 2020 Sep 3;529(4):1131-1136. doi: 10.1016/j.bbrc.2020.05.227. Epub 2020 Aug 4.
8
The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice.
Neuropharmacology. 2019 Sep 1;155:31-43. doi: 10.1016/j.neuropharm.2019.05.013. Epub 2019 May 16.
9
β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress.
Neuropsychopharmacology. 2019 Jun;44(7):1319-1327. doi: 10.1038/s41386-019-0334-7. Epub 2019 Feb 8.
10
Ghrelin/GHSR signaling in the lateral septum ameliorates chronic stress-induced depressive-like behaviors.
Prog Neuropsychopharmacol Biol Psychiatry. 2024 Apr 20;131:110953. doi: 10.1016/j.pnpbp.2024.110953. Epub 2024 Jan 24.

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Mechanisms of the effect of gut microbes on depression through the microbiota-gut-brain axis.
Front Nutr. 2025 Aug 6;12:1634548. doi: 10.3389/fnut.2025.1634548. eCollection 2025.
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To eat or not to eat: A role for ghrelin and LEAP2 in eating disorders?
Neurosci Appl. 2024 Feb 27;3:104045. doi: 10.1016/j.nsa.2024.104045. eCollection 2024.
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Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI.
Nat Commun. 2025 Jul 1;16(1):5608. doi: 10.1038/s41467-025-60730-4.
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Less is more: calorie restriction as a therapeutic for mental health disorders.
Front Psychiatry. 2025 Jun 16;16:1584890. doi: 10.3389/fpsyt.2025.1584890. eCollection 2025.
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An Emerging Role for Gut-Brain Signaling Involving Ghrelin in Chronic Stress.
Adv Exp Med Biol. 2025;1477:205-227. doi: 10.1007/978-3-031-89525-8_7.
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The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders.
Depress Anxiety. 2024 Nov 26;2024:5537319. doi: 10.1155/2024/5537319. eCollection 2024.
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The moderating effect of physical activity in the relationship between sleep quality and BMI in adults with overweight and obesity.
Front Sports Act Living. 2025 Mar 13;7:1455731. doi: 10.3389/fspor.2025.1455731. eCollection 2025.

本文引用的文献

1
Orexin signaling mediates the antidepressant-like effect of calorie restriction.
J Neurosci. 2008 Mar 19;28(12):3071-5. doi: 10.1523/JNEUROSCI.5584-07.2008.
3
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.
J Clin Invest. 2006 Dec;116(12):3229-39. doi: 10.1172/JCI29867. Epub 2006 Oct 19.
4
Acute psychological stress raises plasma ghrelin in the rat.
Regul Pept. 2006 May 15;134(2-3):114-7. doi: 10.1016/j.regpep.2006.02.003. Epub 2006 Mar 6.
5
Direct stimulation of ghrelin secretion by sympathetic nerves.
Endocrinology. 2006 Jun;147(6):2893-901. doi: 10.1210/en.2005-1182. Epub 2006 Mar 9.
6
Ghrelin controls hippocampal spine synapse density and memory performance.
Nat Neurosci. 2006 Mar;9(3):381-8. doi: 10.1038/nn1656. Epub 2006 Feb 19.
7
Mice lacking ghrelin receptors resist the development of diet-induced obesity.
J Clin Invest. 2005 Dec;115(12):3564-72. doi: 10.1172/JCI26002.
8
Neuropeptides in eating disorders.
CNS Spectr. 2004 Jul;9(7):516-22. doi: 10.1017/s1092852900009603.
9
Minireview: From anorexia to obesity--the yin and yang of body weight control.
Endocrinology. 2003 Sep;144(9):3749-56. doi: 10.1210/en.2003-0241.
10
Hypothalamic orexin neurons regulate arousal according to energy balance in mice.
Neuron. 2003 Jun 5;38(5):701-13. doi: 10.1016/s0896-6273(03)00331-3.

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