Cell surface antigens detected in cell lines established from lymphomatous Papio hamadryas and Macaca arctoides monkeys.

Cell surface antigens associated with bone marrow cell cultures from leukemic monkeys of species Papio hamadryas and Macacus arctoides were visualized by means of an indirect immunofluorescence method with sera from leukemic baboons. The same immune serum gave two types of immunofluorescence, depending on the origin of the target cells. Fluorescence of the ring-reaction type was seen with Papio hamadryas bone marrow cell cultures growing in suspension and containing the baboon herpesvirus, whereas the patchy type of fluorescence was noted with monolayer bone marrow cell cultures from Macaca arctoides origin, containing type-C oncornavirus but not the herpesvirus particles. Absorption experiments showed that antibodies responsible for the patchy type of immunofluorescence could be absorbed with a disintegrated type-C baboon oncornavirus, and not with baboon lymphoblastoid cell lines containing the herpesvirus nor with human lymphoblastoid cell lines containing the Epstein-Barr virus.