Markarian D S, Gvaramiia I A, Agrba V Z, Sanguliia I A
Tsitologiia. 1977 Feb;19(2):215-23.
Three suspension cell lines from bone marrow (BMPH-1) and spleens (SPH-2 and SPH-3) of hamadryas baboons with haematosarcoma were presented by analogous lymphoid type cells of a high proliferative activity. The modal class of cells in all the three lines was presented by diploids and pseudodiploids, though there was a significant admixture of heterodiploid and subtriploid cells and cells having various types of marker chromosomes. The reconstructed chromosome 1 and satellite chromosomes dominated among the marker chromosomes indicating their relatively greater mutability. No change was observed in Giemsa-banding during a year's cultivation of all three cell lines. The total number of weakly and poorly differentiating chromosomes in aneuploids is more variable compared to the number of well differentiating chromosomes, due, presumably, to a lesser biological significance of the former.
来自患有血肉瘤的阿拉伯狒狒骨髓(BMPH - 1)和脾脏(SPH - 2和SPH - 3)的三种悬浮细胞系,由具有高增殖活性的类似淋巴细胞类型的细胞组成。所有三个细胞系中的细胞模态类别均由二倍体和假二倍体组成,尽管存在异二倍体和亚三倍体细胞以及具有各种类型标记染色体的细胞的显著混合。在标记染色体中,重建的1号染色体和随体染色体占主导,表明它们具有相对较高的可变性。在所有三个细胞系一年的培养过程中,吉姆萨带型未观察到变化。与分化良好的染色体数量相比,非整倍体中弱分化和低分化染色体的总数变化更大,这可能是由于前者的生物学意义较小。