Tsai R T, Wang C R, Lee G L, Chen M Y, Lee Y T, Chuang C Y, Chen C Y
Department of Internal Medicine, Chung Shan Medical and Dental College Hospital, Taichung, Taiwan, ROC.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1991 May;24(2):213-20.
Fifty-six consecutive patients, 53 males and 3 females aged from 36 to 83 with a mean age of 61.0, all with acute myocardial infarction (AMI), were screened for anticardiolipin antibodies (ACA) by single sampling at time of admission to the medical intensive care unit; results were compared with those for age-matched, healthy controls. IgM and IgG-ACA were measured by an enzyme-linked immunosorbant assay technique. IgG-ACA were detected in 9 patients (16.1%); IgM-ACA were detected in 9 patients (16.1%). Only one of the patients had raised ACA of both isotypes. There was on difference in either ACA levels or frequency of ACA elevation between patients and controls. Risk factors of coronary artery disease showed no significant difference between patients with and without ACA. Low titer of IgG-ACA was found in one of ten patients with reinfarction and/or previous cerebral infarction. In conclusion, single measurements of anticardiolipin antibodies in general AMI patients are unlikely to yield diagnostically important information. The implication of occasional significant elevation of such antibodies in a general AMI population remains to be speculated.
连续56例患者，其中男性53例，女性3例，年龄36至83岁，平均年龄61.0岁，均患有急性心肌梗死（AMI），在入住医疗重症监护病房时单次采样检测抗心磷脂抗体（ACA）；结果与年龄匹配的健康对照者进行比较。采用酶联免疫吸附测定技术检测IgM和IgG-ACA。9例患者（16.1%）检测到IgG-ACA；9例患者（16.1%）检测到IgM-ACA。只有1例患者两种同种型的ACA均升高。患者与对照者之间的ACA水平或ACA升高频率均无差异。冠心病的危险因素在有和没有ACA的患者之间无显著差异。10例再梗死和/或既往有脑梗死的患者中有1例发现低滴度的IgG-ACA。总之，对一般AMI患者单次检测抗心磷脂抗体不太可能获得具有诊断重要性的信息。在一般AMI人群中此类抗体偶尔显著升高的意义仍有待推测。
