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Relationship between serum progesterone and tumor necrosis factor production in postmenopausal women undergoing estrogen/medroxyprogesterone therapy.

作者信息

Stopińska-Głuszak Urszula, Jóźwiak Jarosław, Radomski Dariusz, Głuszak Olgierd, Roszkowski Piotr I, Malejczyk Jacek

机构信息

Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland.

出版信息

Fertil Steril. 2009 Apr;91(4 Suppl):1344-6. doi: 10.1016/j.fertnstert.2008.03.033. Epub 2008 Jun 12.

DOI:10.1016/j.fertnstert.2008.03.033
PMID:18554598
Abstract

Changes in tumor necrosis factor (TNF) production by lipopolysaccharide-stimulated peripheral blood mononuclear cells significantly correlated with serum P levels in postmenopausal women subjected to estrogen/medroxyprogesterone therapy. This may suggest that low physiologic or hormone therapy-related changes of serum P in healthy postmenopausal women may affect an ability of peripheral blood mononuclear leukocytes to produce TNF, thus having an impact on a variety of TNF-dependent physiologic and pathologic phenomena.

摘要

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