Persson B E, Sjöman M, Niklasson F, Ronquist G
Department of Urology, University Hospital, Uppsala, Sweden.
Eur Urol. 1991;19(3):253-6. doi: 10.1159/000473632.
The etiology of prostatitis is not fully understood and several causative factors have been considered in the past. In this study we analyzed the expressed prostatic secretion (EPS) and seminal plasma with regard to uridine, xanthine, urate, creatinine and zinc from patients with prostatitis (the diagnosis was based on symptoms for at least 1 year), together with creatinine, urate and zinc in the serum. In 8 of the patients, a direct comparison of these constituents was performed between EPS and seminal plasma. EPS contained low concentrations of uridine and xanthine and high concentrations of creatinine and zinc as opposed to seminal plasma that displayed a reverse pattern. The mean urate concentration in seminal plasma, exceeding that of EPS by 78%, was rather close to the mean value found in serum but no significant correlation was seen between urate in serum and urate in seminal plasma or EPS. Urate in EPS correlated significantly to xanthine in EPS and such a relationship was also observed between urate and creatinine in EPS. In seminal plasma, urate and xanthine were likewise correlated with each other. On division of the patients into a high-score symptom group and a low-score group, no intergroup differences were found in EPS and seminal plasma constituents. Hence, we found high concentrations especially of uridine and xanthine in seminal plasma, compared with other body fluids, and evidence of a backflow of urine mixing with the prostatic fluid of these patients was seen. We suggest that crystal formation of these metabolites may occur under certain conditions and could constitute a first step in the development of prostatitis-vesiculitis-epididymitis in some cases.
前列腺炎的病因尚未完全明确，过去曾考虑过多种致病因素。在本研究中，我们分析了前列腺炎患者（诊断基于至少1年的症状）的前列腺分泌液（EPS）和精浆中的尿苷、黄嘌呤、尿酸盐、肌酐和锌，以及血清中的肌酐、尿酸盐和锌。在8名患者中，对EPS和精浆中的这些成分进行了直接比较。与精浆呈现相反模式不同，EPS中尿苷和黄嘌呤浓度低，而肌酐和锌浓度高。精浆中尿酸盐的平均浓度比EPS高78%，相当接近血清中的平均值，但血清尿酸盐与精浆或EPS中的尿酸盐之间未发现显著相关性。EPS中的尿酸盐与EPS中的黄嘌呤显著相关，EPS中的尿酸盐与肌酐之间也观察到这种关系。在精浆中，尿酸盐和黄嘌呤同样相互相关。将患者分为高分症状组和低分症状组后，EPS和精浆成分在组间未发现差异。因此，我们发现与其他体液相比，精浆中尤其是尿苷和黄嘌呤的浓度较高，并且在这些患者中可见尿液逆流与前列腺液混合的证据。我们认为，这些代谢产物在某些条件下可能会形成晶体，在某些情况下可能是前列腺炎-精囊炎-附睾炎发展的第一步。
