Sakamoto T, Iwata M, Hirano T
Ocean Research Institute, University of Tokyo, Japan.
Gen Comp Endocrinol. 1991 May;82(2):184-91. doi: 10.1016/0016-6480(91)90182-6.
The kinetics of growth hormone (GH) and prolactin (PRL) in coho salmon (Oncorhynchus kisutch) transferred from fresh water (FW) to seawater (SW) and vice versa were examined to help clarify the osmoregulatory roles of the two hormones during periods of migration to different salinities. Chum salmon GH or PRL was administered by a single injection intraarterially, and metabolic clearance rate (MCR) and secretion rate (SR) of injected hormones were calculated from the disappearance of the hormones from the plasma. When coho salmon smolts were acclimated to SW, MCR, SR, and plasma level of GH in SW-adapted (2-3 weeks) fish were twice as great as those in fish in FW. On the other hand, there was no difference in the kinetics of GH between the adult coho salmon in SW and those adapted to FW (2-3 weeks). The transfer of the adult coho salmon from SW to FW was followed after 2 days by a rise in plasma level and SR of PRL, which tended to stay at high levels after 2-3 weeks. The MCR of PRL increased significantly after 2-3 weeks in FW. These results support the likelihood of an important role of GH in SW adaptation and of PRL in FW adaptation in coho salmon.
研究了银大麻哈鱼（Oncorhynchus kisutch）从淡水（FW）转移到海水（SW）以及相反过程中生长激素（GH）和催乳素（PRL）的动力学，以帮助阐明这两种激素在向不同盐度迁移期间的渗透调节作用。通过动脉内单次注射给予大麻哈鱼GH或PRL，并根据血浆中激素的消失情况计算注射激素的代谢清除率（MCR）和分泌率（SR）。当银大麻哈鱼幼鱼适应SW时，适应SW（2 - 3周）的鱼的MCR、SR和血浆GH水平是FW中鱼的两倍。另一方面，SW中的成年银大麻哈鱼与适应FW（2 - 3周）的成年银大麻哈鱼之间GH的动力学没有差异。成年银大麻哈鱼从SW转移到FW后2天，血浆PRL水平和SR升高，2 - 3周后倾向于保持在高水平。在FW中2 - 3周后PRL的MCR显著增加。这些结果支持了GH在银大麻哈鱼适应SW以及PRL在适应FW中起重要作用的可能性。
