Shaw Souradet Y, Shah Lena, Jolly Ann M, Wylie John L
Cadham Provincial Laboratory, 750 William Ave, Winnipeg, Manitoba R3C3Y1, Canada.
Am J Public Health. 2008 Aug;98(8):1430-7. doi: 10.2105/AJPH.2007.120741. Epub 2008 Jun 12.
We used cluster analysis to subdivide a population of injection drug users and identify previously unknown behavioral heterogeneity within that population.
We applied cluster analysis techniques to data collected in a cross-sectional survey of injection drug users in Winnipeg, Manitoba. The clustering variables we used were based on receptive syringe sharing, ethnicity, and types of drugs injected.
Seven clusters were identified for both male and female injection drug users. Some relationships previously revealed in our study setting, such as the known relationship between Talwin (pentazocine) and Ritalin (methylphenidate) use, injection in hotels, and hepatitis C virus prevalence, were confirmed through our cluster analysis approach. Also, relationships between drug use and infection risk not previously observed in our study setting were identified, an example being a cluster of female crystal methamphetamine users who exhibited high-risk behaviors but an absence or low prevalence of blood-borne pathogens.
Cluster analysis was useful in both confirming relationships previously identified and identifying new ones relevant to public health research and interventions.
我们运用聚类分析对注射吸毒者群体进行细分,并识别该群体中先前未知的行为异质性。
我们将聚类分析技术应用于在马尼托巴省温尼伯市对注射吸毒者进行的横断面调查所收集的数据。我们使用的聚类变量基于共用注射器情况、种族以及注射毒品类型。
男性和女性注射吸毒者均被分为七个类别。我们研究环境中先前揭示的一些关系,如塔尔文(喷他佐辛)和利他林(哌甲酯)使用之间的已知关系、在酒店注射以及丙型肝炎病毒流行率,通过我们的聚类分析方法得到了证实。此外,还识别出了我们研究环境中先前未观察到的吸毒与感染风险之间的关系,例如一群女性冰毒使用者,她们表现出高风险行为,但血源性病原体的感染率较低或不存在感染情况。
聚类分析在确认先前确定的关系以及识别与公共卫生研究和干预相关的新关系方面都很有用。