Gutiérrez Juan Pablo, Cervantes Isabel, Molina Antonio, Valera Mercedes, Goyache Félix
Departamento de Producción Animal, Facultad de Veterinaria, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain.
Genet Sel Evol. 2008 Jul-Aug;40(4):359-78. doi: 10.1186/1297-9686-40-4-359. Epub 2008 Jun 17.
We present here a simple approach to obtain reliable estimates of the effective population size in real world populations via the computation of the increase in inbreeding for each individual (delta F(i)) in a given population. The values of delta F(i) are computed as t-root of 1 - (1 - F(i)) where F(i) is the inbreeding coefficient and t is the equivalent complete generations for each individual. The values of delta F computed for a pre-defined reference subset can be averaged and used to estimate effective size. A standard error of this estimate of N(e) can be further computed from the standard deviation of the individual increase in inbreeding. The methodology is demonstrated by applying it to several simulated examples and to a real pedigree in which other methodologies fail when considering reference subpopulations. The main characteristics of the approach and its possible use are discussed both for predictive purposes and for analyzing genealogies.
我们在此提出一种简单方法，通过计算给定群体中每个个体的近亲繁殖增量（δF(i)），来获得现实世界群体中有效种群大小的可靠估计值。δF(i) 的值通过对 1 - (1 - F(i)) 求 t 次方根来计算，其中 F(i) 是近亲繁殖系数，t 是每个个体的等效完整世代数。为预定义参考子集计算出的 δF 值可以求平均值并用于估计有效大小。可以根据个体近亲繁殖增量的标准差进一步计算 N(e) 估计值的标准误差。通过将该方法应用于几个模拟示例和一个真实谱系来进行演示，在考虑参考亚群体时，其他方法在该真实谱系中失效。本文还讨论了该方法的主要特征及其在预测目的和分析谱系方面的可能用途。
