1例微分化低增生性急性髓系白血病M0患者的15号染色体长臂缺失。
Deletion of chromosome arm 15q in a case of minimally differentiated hypoplastic AML-M0.
作者信息
Fujieda Atsushi, Masuya Masahiro, Kitano Shigehisa, Miyazaki Kana, Yazaki Akira, Sugimoto Yuka, Usui Eiji, Miyata Eri, Shibasaki Tetsunori, Yamamura Kentaro, Ohishi Kohshi, Nishii Kazuhiro, Nakase Kazunori, Takeuchi Toshiaki, Katayama Naoyuki
机构信息
Department of Hematology and Oncology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507 Japan.
出版信息
Cancer Genet Cytogenet. 2008 Jul;184(1):57-61. doi: 10.1016/j.cancergencyto.2008.03.010.
Deletion of the long arm of chromosome 15 is known as a rare but recurrent chromosomal abnormality in myeloid malignancies. We report a novel case of minimally differentiated hypoplastic acute myeloid leukemia (AML M0) in a patient who initially had a normal karyotype, but clonal interstitial deletion of chromosome 15, del(15)(q11.2q22), coincided with increment of leukemic cells a year later. We also summarize 18 published cases with myeloid malignancies and this chromosomal abnormality.
15号染色体长臂缺失是髓系恶性肿瘤中一种罕见但反复出现的染色体异常。我们报告了一例初诊时核型正常的微小分化型低增生性急性髓系白血病（AML M0）新病例，该患者一年后出现15号染色体克隆性间质缺失del(15)(q11.2q22)，同时白血病细胞增多。我们还总结了18例已发表的伴有这种染色体异常的髓系恶性肿瘤病例。
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