Cogneau J, Blanchecotte F, Halimi J-M
Service de néphrologie-immunologie clinique, hôpital Bretonneau, CHU Tours, France.
Ann Biol Clin (Paris). 2008 May-Jun;66(3):285-90. doi: 10.1684/abc.2008.0237.
The incidence of End-stage renal disease increases in most Western countries including in France. Few data regarding the incidence of mild renal dysfunction are scarce in the general population. The aim of the present study (BIRD study) was to collect in a database the results of creatinine measurements in the general population from a large area (Région Centre), and assess the percentage of patients with mild renal dysfunction (using the Cockcroft formula). This database was financed by the URCAM (social security from the Région Centre). Data from laboratories were regularly sent to the database through an automatic process. Regular ou emails then were sent to physicians in charge of the patient in order to collect information on patient's history of renal and cardiovascular disease. We were able to collect more than 100,000 creatinine measurements (in roughly 70,000 patients) with the participation of 27 laboratories in the Région Centre. The percentage of patients with glomerular filtration rate < 60 mL/min was 10% in patients 60 and older, 25% in patients with 70 and older and 75% in patients 75 and older. Data coming from the physicians indicated that patients with renal risk were also at high cardiovascular risk. However, these patients are not systematically identified as having renal dysfunction, which explains why diagnosis and appropriate management often are delayed (sonogram was performed in only 25% of patients and 75% of patients never saw a nephrologist). Information regarding assessment of renal function and appropriate management should improve this situation.
包括法国在内的大多数西方国家,终末期肾病的发病率都在上升。普通人群中关于轻度肾功能不全发病率的数据很少。本研究(BIRD研究)的目的是在一个数据库中收集来自大面积区域(中央大区)普通人群的肌酐测量结果,并评估轻度肾功能不全患者的比例(使用Cockcroft公式)。该数据库由URCAM(中央大区社会保障机构)资助。实验室数据通过自动流程定期发送到数据库。然后定期通过电子邮件向负责患者的医生发送信息,以收集患者的肾脏和心血管疾病病史信息。在中央大区27个实验室的参与下,我们能够收集到超过10万次肌酐测量结果(约7万名患者)。60岁及以上患者中肾小球滤过率<60 mL/分钟的患者比例为10%,70岁及以上患者中为25%,75岁及以上患者中为75%。来自医生的数据表明,有肾脏风险的患者也有很高的心血管风险。然而,这些患者并没有被系统地识别为患有肾功能不全,这就解释了为什么诊断和适当治疗常常被延误(仅25%的患者进行了超声检查,75%的患者从未看过肾病专家)。关于肾功能评估和适当治疗的信息应该会改善这种情况。