Liu Jian, Yu Xue-fang, Zong Rui-kai
Department of Rheumatology, the First Affiliated Hospital, Anhui College of Traditional Chinese Medicine, Hefei, Anhui Province 230031, China.
Zhong Xi Yi Jie He Xue Bao. 2008 Jun;6(6):606-10. doi: 10.3736/jcim20080612.
To observe the effects of Xinfeng Capsule (XFC), a compound Chinese herbal medicine, on behaviors and myocardial ultrastructure in adjuvant arthritis (AA) rats.
Fifty-five rats were randomly divided into normal control group, untreated group, methotrexate (MTX) group, Tripterygium wilfordii glycosides tablet (TGT) group and XFC group. There were 11 rats in each group. Except for those in the normal control group, the rats in the other groups were all intracutaneously given 0.1 ml Freund's complete adjuvant in the right hind limb. Changes of behaviors and myocardial ultrastructure of the rats in different groups were observed.
Voix pedis' swelling and arthritis index in XFC, MTX and TPT groups were all obviously improved as compared with the untreated group. After XFC treatment, the autonomic activities were obviously increased, number of errors in exercise period and test period were obviously decreased, step-down latency (SDL) was lengthened and escape latency (EL) was shortened. Overall structure of myocardial myofibril and the majority of cristae was intact in XFC group. The effects of XFC in improving the behaviors and myocardial ultrastructure were better than those of MTX and TPT.
Changes of behaviour and myocardial ultrastructure of AA rats can be observed. XFC can improve the myocardial ultrastructure of AA rats as well as their behaviors.
观察复方中药新风胶囊（XFC）对佐剂性关节炎（AA）大鼠行为及心肌超微结构的影响。
将55只大鼠随机分为正常对照组、未治疗组、甲氨蝶呤（MTX）组、雷公藤多苷片（TGT）组和XFC组，每组11只。除正常对照组外，其余各组大鼠右后肢皮内注射0.1 ml弗氏完全佐剂。观察不同组大鼠行为及心肌超微结构的变化。
与未治疗组相比，XFC组、MTX组和TPT组大鼠足跖肿胀度和关节炎指数均明显改善。XFC治疗后，自主活动明显增加，运动期和测试期错误次数明显减少，跳下潜伏期（SDL）延长，逃避潜伏期（EL）缩短。XFC组心肌肌原纤维的整体结构和大部分嵴完整。XFC在改善行为和心肌超微结构方面的效果优于MTX和TPT。
可观察到AA大鼠行为及心肌超微结构的变化。XFC可改善AA大鼠的心肌超微结构及其行为。
