Mollo F, Bellis D, Delsedime L, Bernardi P, Ardissone F, Piolatto G, Andrion A
Department of Biomedical Sciences and Human Oncology, University of Turin, Italy.
IARC Sci Publ. 1991(112):141-7.
In many instances, only post-mortem examination can provide probative data about (i) the presence of lung cancer and (ii) its relationship to exposure to asbestos. Moreover, the results of an autopsy may suggest that a thorough investigation of occupational history should be carried out, since such information is rarely recorded in clinical records. We considered pathological indicators for selecting subjects who had a high likelihood of previous occupational exposure to asbestos. The positive predictive value of pleural plaques ranged from 20 to 75%, depending on their size and on the concentrations of asbestos bodies and uncoated mineral fibres in the lung. The probability of no exposure was greater than 90% if neither asbestos bodies nor uncoated mineral fibres were found. Another purpose of our work on lung cancer and exposure to asbestos was to investigate the relationships between exposure and the occurrence of specific cell types of lung cancer in an autopsied population. Both work history and asbestos body count were considered. The matched analysis showed some tendency towards an association between the occurrence of adenocarcinoma and the presence of indicators of exposure to asbestos.
在许多情况下，只有尸检才能提供有关（i）肺癌的存在以及（ii）其与接触石棉之间关系的确凿数据。此外，尸检结果可能表明应彻底调查职业史，因为此类信息在临床记录中很少被记录。我们考虑了用于选择先前有高度职业接触石棉可能性的受试者的病理指标。胸膜斑的阳性预测值在20%至75%之间，这取决于它们的大小以及肺中石棉小体和未包被矿物纤维的浓度。如果未发现石棉小体和未包被矿物纤维，则无接触的概率大于90%。我们关于肺癌与接触石棉的研究的另一个目的是在尸检人群中调查接触与特定细胞类型肺癌发生之间的关系。工作史和石棉小体计数均被考虑在内。配对分析显示腺癌的发生与石棉接触指标的存在之间有某种关联趋势。
