Böhrer H, Zhang C H, Krier C
Klinik für Anästhesiologie, Ruprecht-Karls-Universität Heidelberg.
Infusionstherapie. 1991 Apr;18(2):96-100.
To assess the loss of drugs to in-line filters, concentrations of tobramycin, vancomycin, and phenobarbitone were determined in vitro in samples recovered upstream and downstream of the filter. Binding of the drugs to new filters was higher than to used filters. With bolus administration, the concentrations of vancomycin and phenobarbitone were reduced by 1% when using old filters and by 4% when using new filters. Tobramycin concentrations were reduced by 7 and 12%, respectively. With continuous administration of the drugs, binding was highest during the first half hour. Differences between new and used filters were also seen with continuous administration: The cumulative loss was 5% higher with new than with old filters. This difference in binding between filters may stem from a saturation of free binding sites. Tobramycin showed the highest binding to the in-line filter. The extent of adsorption of tobramycin to intravenous filters may be considered moderately important in adult patients. The adsorption of vancomycin and phenobarbitone is not clinically relevant in adult patients.
为评估药物在线过滤器的损失情况，在过滤器上游和下游回收的样品中对妥布霉素、万古霉素和苯巴比妥的浓度进行了体外测定。药物与新过滤器的结合高于与使用过的过滤器的结合。推注给药时，使用旧过滤器时万古霉素和苯巴比妥的浓度降低1%，使用新过滤器时降低4%。妥布霉素浓度分别降低7%和12%。持续给药时，给药后半小时内结合率最高。持续给药时，新过滤器和使用过的过滤器之间也存在差异：新过滤器的累积损失比旧过滤器高5%。过滤器之间这种结合差异可能源于游离结合位点的饱和。妥布霉素与在线过滤器的结合最高。在成年患者中，妥布霉素对静脉过滤器的吸附程度可能被认为具有中等重要性。万古霉素和苯巴比妥的吸附在成年患者中无临床相关性。
