依达拉奉可提高未复苏的失血性休克大鼠的存活率。

Edaravone improves the survival of rats subjected to hemorrhagic shock without resuscitation.

作者信息

Uji Yoshitaka, Yamamoto Hiroshi, Mori Tsuyoshi, Akabori Hiroya, Tsuchihashi Hiroshi, Shimizu Tomoharu, Endo Yoshihiro, Tani Tohru

机构信息

Department of Surgery, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, 520-2121, Japan.

出版信息

Surg Today. 2008;38(5):476-7. doi: 10.1007/s00595-007-3666-6. Epub 2008 Apr 30.

DOI:10.1007/s00595-007-3666-6

PMID:18560976

Abstract

Our aim in this study was to find out whether edaravone (3-methyl-1-phenyl-pyrazolin-5-one, MCI-186), a novel free radical scavenger, improved the survival rate in a rat hemorrhagic shock (HS) model. Fifty male Sprague-Dawley rats were divided randomly into an edaravone group and a saline group. Both groups were subjected to HS by inducing a mean arterial pressure of 30 mmHg for 60 min without resuscitation. The edaravone group was divided into four subgroups based on when edaravone was given: 0, 15, 30, or 60 min after HS. The saline group was given saline immediately after HS. We evaluated the 24-h survival rate in each group. The survival rate of the edaravone subgroup given edaravone immediately after HS was significantly better than that of the saline group. Edaravone improved the survival rate in a rat HS without resuscitation model. Edaravone was most effective when given immediately after HS.

摘要

本研究的目的是探究新型自由基清除剂依达拉奉（3-甲基-1-苯基-吡唑啉-5-酮，MCI-186）是否能提高大鼠失血性休克（HS）模型的存活率。将50只雄性Sprague-Dawley大鼠随机分为依达拉奉组和生理盐水组。两组均通过诱导平均动脉压至30 mmHg并持续60分钟且不进行复苏来造成失血性休克。依达拉奉组根据依达拉奉给药时间分为四个亚组：失血性休克后0、15、30或60分钟给药。生理盐水组在失血性休克后立即给予生理盐水。我们评估了每组的24小时存活率。失血性休克后立即给予依达拉奉的依达拉奉亚组的存活率显著高于生理盐水组。依达拉奉提高了未复苏的大鼠失血性休克模型的存活率。失血性休克后立即给予依达拉奉最为有效。