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用于小动物锥形束CT的基于软件的呼吸门控

Software-based respiratory gating for small animal conebeam CT.

作者信息

Farncombe T H

机构信息

Department of Nuclear Medicine, Hamilton Health Sciences, Hamilton, Ontario L8N 3Z5, Canada.

出版信息

Med Phys. 2008 May;35(5):1785-92. doi: 10.1118/1.2905031.

Abstract

In volumetric CT imaging of small animals, the breathing motion of the lungs during the image acquisition process results in inconsistent projection data being acquired. When reconstructed, these inconsistent data may produce images with reduced spatial resolution and image contrast. In order to minimize these effects, various approaches have been utilized to capture the respiratory signal of the animals under study and to only obtain CT data at specific moments in the respiratory cycle. These approaches typically utilize hardware-based physiological monitoring equipment in order to record the respiratory signal and either prospectively or retrospectively correlate this signal with acquired CT projection data. In this work, a new method of CT respiratory gating is described that does not rely on external physiological monitoring. Rather, determination of the respiratory phase of the animal is performed by postprocessing the acquired projection data. With this approach, any CT projection data can be respiratory gated with minimal effort. Validation of the method has been performed using a dynamic phantom and accuracy in tidal volumes determined to be within 16%. Rats and mice have been scanned and processed using the proposed method and compared to physiological-based measurement. With the proposed method, image quality is significantly improved in addition to providing quantitative information regarding tidal lung volumes.

摘要

在小动物的容积CT成像中,图像采集过程中肺部的呼吸运动会导致采集到的投影数据不一致。重建时,这些不一致的数据可能会产生空间分辨率和图像对比度降低的图像。为了将这些影响降至最低,人们采用了各种方法来捕捉受试动物的呼吸信号,并仅在呼吸周期的特定时刻获取CT数据。这些方法通常利用基于硬件的生理监测设备来记录呼吸信号,并将该信号与采集到的CT投影数据进行前瞻性或回顾性关联。在这项工作中,描述了一种新的CT呼吸门控方法,该方法不依赖于外部生理监测。相反,通过对采集到的投影数据进行后处理来确定动物的呼吸阶段。采用这种方法,任何CT投影数据都可以轻松地进行呼吸门控。已使用动态体模对该方法进行了验证,确定潮气量的准确度在16%以内。已使用所提出的方法对大鼠和小鼠进行扫描和处理,并与基于生理的测量结果进行比较。使用所提出的方法,除了提供有关肺潮气量的定量信息外,图像质量也得到了显著改善。

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