Ahn Anna, Frishman William H, Gutwein Andrew, Passeri Jonathan, Nelson Michael
Department of Medicine, Long Island Jewish Medical Center/Albert Einstein College of Medicine, New Hyde Park, New York, USA.
Cardiol Rev. 2008 Jul-Aug;16(4):163-71. doi: 10.1097/CRD.0b013e3181620e3b.
Angiogenesis is the biologic process of forming new blood vessels and is being investigated as an innovative therapeutic approach to help manage ischemic heart disease and peripheral vascular disease. Research studies have identified various angiogenic growth factors and progenitor cells that can enhance new blood vessel formation. Preclinical investigations in animal models have explored the potential use of growth factors with and without progenitor cells to treat myocardial ischemia. The results of clinical trials with growth factor infusions and gene therapy techniques to enhance growth factor production have shown some promise, but therapeutic angiogenesis remains at an early stage of development.
血管生成是形成新血管的生物学过程，目前正作为一种创新治疗方法进行研究，以帮助治疗缺血性心脏病和外周血管疾病。研究已经确定了多种可促进新血管形成的血管生成生长因子和祖细胞。在动物模型中进行的临床前研究探讨了使用生长因子（有或没有祖细胞）治疗心肌缺血的潜在用途。使用生长因子输注和基因治疗技术来提高生长因子产生的临床试验结果已显示出一些希望，但治疗性血管生成仍处于早期发展阶段。
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