Agarwal Shipra, Suri Vaishali, Rishi Arvind, Shukla Bhaskar, Garg Ajay, Sharma Mehar Chand, Sinha Sumit, Sarkar Chitra
Department of Pathology, All India Institute of Medical Sciences, New Delgi, India.
Neuropathology. 2009 Feb;29(1):96-100. doi: 10.1111/j.1440-1789.2008.00933.x. Epub 2008 Jun 17.
Glioneuronal tumor with neuropil-like islands (GTNI) is a distinctive and rare tumor characterized by both glial and neuronal differentiation. However, unlike other mixed glioneuronal tumors, which are characterized by a favorable prognosis, this neoplasm has been found to be potentially aggressive. We report here a case arising in a 60-year old male patient who presented with seizures, forgetfulness and right-sided hemiparesis, due to a left frontal lobe tumor. Unlike most cases described in the literature, the present tumor was unique in its radiological appearance, which was cystic. On microscopic evaluation, the glial component was chiefly gemistocytic punctuated by neuropil-like islands. Strong nuclear immunolabeling of p53 and absence of 1p/19q deletion by fluorescence in situ hybridization assay were consistent with those in previous reports.
伴有神经毡样岛的胶质神经元肿瘤（GTNI）是一种独特的罕见肿瘤，其特征为同时具有胶质和神经元分化。然而，与其他预后良好的混合性胶质神经元肿瘤不同，这种肿瘤已被发现具有潜在侵袭性。我们在此报告一例发生于一名60岁男性患者的病例，该患者因左额叶肿瘤出现癫痫发作、健忘和右侧偏瘫。与文献中描述的大多数病例不同，本肿瘤在影像学表现上具有独特性，为囊性。在显微镜评估下，胶质成分主要为肥胖型星形细胞，散在分布着神经毡样岛。p53的强核免疫标记以及荧光原位杂交检测显示1p/19q无缺失，与先前报告一致。
