Balin Samuel J, Platt Jeffrey L, Cascalho Marilia
Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Pediatr Transplant. 2008 Aug;12(5):510-5. doi: 10.1111/j.1399-3046.2007.00867.x. Epub 2008 Jun 28.
Organ transplants between genetically different individuals elicit powerful immune responses that invariably cause rejection in the absence of immune suppression. Among the immune responses elicited by organ allografts, B-cell responses causing antibody-mediated rejection are one of the most vexing. However, recent advances in the field indicate that B cells and antibodies' contribution to immunity extends well beyond the traditional functions ascribed to antibodies. Here we review "non-humoral" functions of B cells and the implications of these functions to transplantation.
在基因不同的个体之间进行器官移植会引发强烈的免疫反应,在没有免疫抑制的情况下,这种反应总是会导致排斥反应。在器官同种异体移植引发的免疫反应中,导致抗体介导排斥反应的B细胞反应是最棘手的问题之一。然而,该领域最近的进展表明,B细胞和抗体对免疫的贡献远远超出了传统上归因于抗体的功能。在这里,我们综述B细胞的“非体液”功能以及这些功能对移植的影响。