Rana S V, Sinha S K, Sikander A, Bhasin D K, Singh K
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Trop Gastroenterol. 2008 Jan-Mar;29(1):23-5.
Approximately 20% of the general population has irritable bowel syndrome. Despite this high prevalence, the cause of irritable bowel syndrome is unknown. There is no data available concerning the prevalence of small intestinal bacterial overgrowth in North Indian patients with irritable bowel syndrome.
This study evaluated the prevalence of small intestinal bacterial overgrowth in patients with irritable bowel syndrome compared with healthy controls.
This study included 225 consecutive patients of irritable bowel syndrome between the ages 20 and 65 years attending the gastroenterology clinics. Diagnosis of irritable bowel syndrome was made according to the Rome II criteria. Small intestinal bacterial overgrowth was estimated by using the non-invasive glucose hydrogen breath test.
Of 225 patients of irritable bowel syndrome, 160 (71.1%) were male and 65 (28.9%) were female. Of 100 controls, 65 (65%) were male and 35 (35%) female. The prevalence of small intestinal bacterial overgrowth was 25 of 225 (11.1%) patients with irritable bowel syndrome and 1 of 100 (1%) in apparently healthy controls. This difference was statistically significant. The prevalence of small intestinal bacterial overgrowth in male and female patients was not significantly different.
This study indicates that the prevalence of small intestinal bacterial overgrowth in irritable bowel syndrome patients from North India is approximately 11.1%, which is lower than the reported prevalence.
普通人群中约20%患有肠易激综合征。尽管患病率很高，但肠易激综合征的病因尚不清楚。目前尚无关于北印度肠易激综合征患者小肠细菌过度生长患病率的数据。
本研究评估了肠易激综合征患者与健康对照者相比小肠细菌过度生长的患病率。
本研究纳入了225例年龄在20至65岁之间连续就诊于胃肠病诊所的肠易激综合征患者。根据罗马II标准诊断肠易激综合征。采用非侵入性葡萄糖氢呼气试验评估小肠细菌过度生长情况。
225例肠易激综合征患者中，男性160例（71.1%），女性65例（28.9%）。100名对照者中，男性65例（65%），女性35例（35%）。225例肠易激综合征患者中有25例（11.1%）存在小肠细菌过度生长，100名明显健康的对照者中有1例（1%）存在小肠细菌过度生长。这种差异具有统计学意义。男性和女性患者小肠细菌过度生长的患病率无显著差异。
本研究表明，北印度肠易激综合征患者小肠细菌过度生长的患病率约为11.1%，低于报道的患病率。
