用于肺部给药的喷雾干燥结核疫苗。
Spray drying TB vaccines for pulmonary administration.
作者信息
Fourie P B, Germishuizen W A, Wong Y-L, Edwards D A
机构信息
Chief Scientific Officer Medicine in Need (Mend), MRC Building, PO Box 12660, Queenswood, 0121 Pretoria, South Africa.
出版信息
Expert Opin Biol Ther. 2008 Jul;8(7):857-63. doi: 10.1517/14712598.8.7.857.
BACKGROUND
New developments in materials science provide innovative technologies that allow mucosal immunization against tuberculosis. Recent studies report that spray-drying Mycobacterium bovis Bacillus Calmette-Guérin (BCG) allows efficient aerosol delivery of TB vaccines to the lung.
OBJECTIVES
To consider powder formulation of BCG for inhalation by spray-drying and its potential application to other vaccines given the unique challenges in the process, formulation and delivery.
METHODS
Description of current advances in spray-drying and aerosol delivery, and its application to preparation of BCG TB vaccine for inhalation. Special consideration is given to physical properties, viability, stability and delivery aspects.
RESULTS/CONCLUSION: Spray-drying generates powders with excellent dispersion qualities suitable for targeted delivery to the deep lung. TB vaccine for inhalation prepared by spray-drying is feasible, low-cost and pharmaceutically scaleable.
背景
材料科学的新进展提供了创新技术，可实现针对结核病的黏膜免疫。最近的研究报告称，喷雾干燥卡介苗（BCG）可将结核疫苗高效气溶胶递送至肺部。
目的
考虑通过喷雾干燥制备用于吸入的卡介苗粉末制剂，以及鉴于该过程、制剂和递送方面的独特挑战，其在其他疫苗中的潜在应用。
方法
描述喷雾干燥和气溶胶递送的当前进展，及其在制备用于吸入的卡介苗结核疫苗中的应用。特别考虑物理性质、活力、稳定性和递送方面。
结果/结论：喷雾干燥产生具有优异分散质量的粉末，适用于靶向递送至深部肺部。通过喷雾干燥制备的用于吸入的结核疫苗是可行的、低成本的且可按制药规模生产。
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