Bendtzen Klaus
Rigshospitalet, Institut for Inflammationsforskning IIR7521, København Ø.
Ugeskr Laeger. 2008 Jun 9;170(24):2110-5.
Innate and adaptive immunity has evolved as a defence against infections and as an important repair mechanism after physical injury. If elimination of microbes and healing is not achieved, or if the immune system is dysregulated, chronic inflammation ensues. Immune cells become engaged in prolonged reactions with other cell types in vessels and organs, frequently with superimposed autoreactive T-cells and autoantibody-producing B-cells/plasma cells. The processes are distinguished on the basis of clinical manifestations in organ-specific and systemic inflammatory diseases. The underlying factors of these diseases are generally unknown.
先天免疫和适应性免疫已经进化成为抵御感染的防御机制以及物理损伤后的重要修复机制。如果无法清除微生物和实现愈合，或者如果免疫系统失调，就会引发慢性炎症。免疫细胞会与血管和器官中的其他细胞类型发生长时间反应，通常还会伴有叠加的自身反应性T细胞和产生自身抗体的B细胞/浆细胞。这些过程根据器官特异性和全身性炎症疾病的临床表现来区分。这些疾病的潜在因素通常尚不清楚。
