种族对晚期和复发性宫颈癌女性铂类化疗耐受性及临床结局的影响：妇科肿瘤学组3项研究的汇总分析
Influence of race on tolerance of platinum-based chemotherapy and clinical outcomes in women with advanced and recurrent cervical cancer: a pooled analysis of 3 Gynecologic Oncology Group studies.
作者信息
Plaxe Steven C, Brooks Sandra E, Tian Chunquiao, Bloss Jeffrey D, Moore David H, Long Harry J
机构信息
Division of Gynecologic Oncology, University of California, San Diego, San Diego, CA, USA.
出版信息
Am J Obstet Gynecol. 2008 Nov;199(5):539.e1-6. doi: 10.1016/j.ajog.2008.04.038. Epub 2008 Jun 20.
OBJECTIVE
This study was undertaken to compare toxicity and outcomes from cisplatin-based combination chemotherapy for black and white women with advanced /recurrent cervical cancer.
STUDY DESIGN
Frequencies of grade 3 and 4 toxicities, response, and survival were compared by race using data from 3 Gynecologic Oncology Group studies.
RESULTS
Black women experienced significantly less grade 3 and 4 neutropenia (63% vs 82%), leukopenia (58% vs 79%), thrombocytopenia (10% vs 23%), and adverse events of any nature (84% vs 93%) compared with white women. Black patients were not at increased risk of disease progression (adjusted relative risk, 1.11; 95% confidence interval, 0.88-1.38; P = .382) or death (adjusted relative risk, 1.02; 95% confidence interval, 0.82-1.26; P = .893).
CONCLUSION
Cisplatin-based chemotherapy delivered in a protocol setting for advanced/recurrent carcinoma of the cervix appears better tolerated by black women.
目的
本研究旨在比较晚期/复发性宫颈癌的黑人女性和白人女性接受以顺铂为基础的联合化疗的毒性和治疗结果。
研究设计
使用妇科肿瘤学组3项研究的数据，按种族比较3级和4级毒性、缓解率及生存率的频率。
结果
与白人女性相比，黑人女性出现3级和4级中性粒细胞减少（63%对82%）、白细胞减少（58%对79%）、血小板减少（10%对23%）及任何性质不良事件（84%对93%）的情况明显较少。黑人患者疾病进展风险（校正相对风险，1.11；95%置信区间，0.88 - 1.38；P = 0.382）或死亡风险（校正相对风险，1.02；95%置信区间，0.82 - 1.26；P = 0.893）并未增加。
结论
在晚期/复发性宫颈癌治疗方案中采用的以顺铂为基础的化疗，黑人女性似乎耐受性更好。
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