[子宫内膜间质肉瘤和子宫平滑肌肿瘤的免疫组织化学研究]
[Immunohistochemical study of endometrial stromal sarcoma and smooth-muscle tumors of the uterus].
作者信息
Farah-Klibi F, Ben Hamouda S, Ben Romdhane S, Sfar R, Koubaa A, Ben Jilani S, Zermani R
机构信息
Service d'anatomie et de cytologie pathologiques, hôpital Charles-Nicolle, boulevard 9-Avril-1938, 1006 Tunis, Tunisie.
出版信息
J Gynecol Obstet Biol Reprod (Paris). 2008 Sep;37(5):457-62. doi: 10.1016/j.jgyn.2008.05.002. Epub 2008 Jun 18.
OBJECTIVES
Positive and differential diagnoses of mesenchymal tumors of the uterus may be sometimes problematic. The purpose of this study was to evaluate the utility of a panel of antibodies in this diagnosis.
MATERIALS AND METHODS
The expression of AML, desmin, h-caldesmon and CD10 was studied in nine endometrial stromal sarcomas (SSE), two leiomyosarcomas (LMS) and 10 highly-cellular leiomyoma (HCL).
RESULTS
AML positivity was found in five SSE, in all HCL and in only one LMS. Desmin expression was found in two SSE, in all HCL and LMS. H-caldesmon was negative in all SSE, positive in all HCL and in one case of LMS. CD10 was expressed in two-third of SSE. However, neither HCL nor LMS was marqued.
CONCLUSION
CD10 is the most specific antibody of SSE. It seems to have the best value in the diagnosis of mesenchymal tumors in association with desmin and h-caldesmon, specific markers of smooth-muscle differentiation.
目的
子宫间叶肿瘤的阳性诊断和鉴别诊断有时可能存在问题。本研究的目的是评估一组抗体在该诊断中的效用。
材料与方法
研究了9例子宫内膜间质肉瘤（SSE）、2例平滑肌肉瘤（LMS）和10例富于细胞平滑肌瘤（HCL）中AML、结蛋白、h-钙调蛋白和CD10的表达情况。
结果
在5例SSE、所有HCL和仅1例LMS中发现AML阳性。在2例SSE、所有HCL和LMS中发现结蛋白表达。所有SSE中h-钙调蛋白均为阴性，所有HCL及1例LMS中为阳性。三分之二的SSE表达CD10。然而，HCL和LMS均未标记。
结论
CD10是SSE最具特异性的抗体。与结蛋白和h-钙调蛋白（平滑肌分化的特异性标志物）联合使用时，它在间叶肿瘤的诊断中似乎具有最佳价值。
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