Ennezat Pierre V, Lamblin Nicolas, Mouquet Frédéric, Tricot Olivier, Quandalle Philippe, Aumégeat Valérie, Equine Octave, Nugue Olivier, Segrestin Benoit, de Groote Pascal, Bauters Christophe
Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
Eur Heart J. 2008 Aug;29(16):1992-9. doi: 10.1093/eurheartj/ehn267. Epub 2008 Jun 20.
Following myocardial infarction (MI), both age and left ventricular (LV) remodelling are associated with an increased risk of adverse events. We tested the hypothesis that the increased incidence of heart failure following MI in elderly patients is associated with a greater propensity for LV remodelling.
We monitored 266 patients with anterior MI. Echocardiographic studies were performed at hospital discharge, at 3 months, and at 1 year following hospitalization for MI. A clinical follow-up examination was performed after 3 years. Left ventricular remodelling was documented by an increase in LV end-diastolic volume after 1 year. Left ventricular end-diastolic and end-systolic volumes did not differ with age for all time points studied. Left ventricular remodelling was observed in 31, 26, 34, and 34% of patients <48, 48-57, 58-71, and >71 years of age, respectively. The 3 year heart-failure hospitalization rates were 1.9, 1.5, 11.0, and 20.3% for patients <48, 48-57, 58-71, and >71 years of age, respectively. Hospitalization for heart failure was more frequent in older patients.
We found that age was a major determinant of subsequent re-hospitalization for heart failure. However, we found no significant association between age and the LV remodelling process.
心肌梗死（MI）后，年龄和左心室（LV）重构均与不良事件风险增加相关。我们检验了这样一个假设，即老年患者MI后心力衰竭发生率增加与LV重构倾向更大有关。
我们监测了266例前壁MI患者。在MI住院出院时、3个月时和1年后进行超声心动图研究。3年后进行临床随访检查。1年后LV舒张末期容积增加记录为LV重构。在所有研究时间点，LV舒张末期和收缩末期容积在各年龄组间无差异。年龄<48岁、48 - 57岁、58 - 71岁和>71岁的患者中，LV重构发生率分别为31%、26%、34%和34%。年龄<48岁、48 - 57岁、58 - 71岁和>71岁的患者3年心力衰竭住院率分别为1.9%、1.5%、11.0%和20.3%。老年患者心力衰竭住院更为频繁。
我们发现年龄是随后因心力衰竭再次住院的主要决定因素。然而，我们发现年龄与LV重构过程之间无显著关联。
