Aarstad Anne K H, Aarstad Hans J, Olofsson Jan
Department of Surgical Sciences, Faculty of Medicine, University of Bergen, Bergen, Norway.
Acta Oncol. 2008;47(5):879-90. doi: 10.1080/02841860701798858.
The aim of the present study was to investigate to what extent personality and choice of coping predicted self-reported quality of life (QoL) in successfully treated head and neck squamous cell carcinoma (HNSCC) patients.
We determined QoL by the European Organization for Research and Treatment of Cancer Quality of life Questionnaire (EORTC-QLQ) C30/H&N35, personality by the Eysenck Personality Inventory and coping by the COPE questionnaire. All patients younger than 80 years who had been diagnosed with HNSCC in Western Norway in the period from 1992 to1997, and who had survived until 1999, were sampled. Ninety-six patients (90% response rate) were included 48+/-2 months after diagnosis. Fifty-five of 58 eligible patients were interviewed a second time 47+/-1 months after the first interview where neuroticism and QoL questionnaires were answered.
Numerical T stage was inversely associated with the second QoL scores (CV: 10-24%). High neuroticism generally predicted low secondary QoL scores both directly (common variance: 17-25%) and adjusted by the QoL values measured simultaneously as the neuroticism (CV: 11-25%). Avoidance focused, problem focused, drinking to cope and coping by humor all predicted QoL scores (CV: 8.5-15%). The present association pattern could still be shown when adjusted for gender, age and educational level when studied by multiple regression analyses.
In conclusion, a high T stage, high neuroticism, coping by humor and coping by problem solving directly predicted low QoL whereas neuroticism was also associated with QoL through avoidance coping.
本研究的目的是调查人格和应对方式在多大程度上预测了成功治疗的头颈部鳞状细胞癌（HNSCC）患者自我报告的生活质量（QoL）。
我们通过欧洲癌症研究与治疗组织生活质量问卷（EORTC-QLQ）C30/H&N35来测定生活质量，通过艾森克人格问卷来测定人格，通过应对方式问卷来测定应对方式。对1992年至1997年期间在挪威西部被诊断为HNSCC且存活至1999年的所有80岁以下患者进行抽样。96名患者（应答率90%）在诊断后48±2个月被纳入研究。58名符合条件的患者中有55名在第一次访谈后47±1个月接受了第二次访谈，此次访谈中回答了神经质和生活质量问卷。
数字T分期与第二次生活质量评分呈负相关（变异系数：10 - 24%）。高神经质通常直接预测较低的二次生活质量评分（共同方差：%17 - 25），并通过与神经质同时测量的生活质量值进行调整（变异系数：11 - 25%）。回避聚焦、问题聚焦、借酒消愁和幽默应对方式均能预测生活质量评分（变异系数：8.5 - 15%）。在通过多元回归分析进行研究时，调整性别、年龄和教育水平后，仍可呈现当前的关联模式。
总之，高T分期、高神经质、幽默应对和问题解决应对方式直接预测低生活质量，而神经质还通过回避应对与生活质量相关。
