Dabisch Paul A, Horsmon Michael S, Taylor James T, Muse William T, Miller Dennis B, Sommerville Douglas R, Mioduszewski Robert J, Thomson Sandra
Operational Toxicology Team, U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010-5424, USA.
Cutan Ocul Toxicol. 2008;27(2):123-33. doi: 10.1080/15569520802064376.
The present study was undertaken to investigate the miotic potency of soman vapor in the rat, as well as gender differences in the miotic response to soman vapor that have been reported previously for other nerve agents. The results of the present study demonstrate that the miotic potency of soman vapor is significantly less than that of other nerve agents, and that female rats are 2.5-3.0 times more sensitive to soman vapor than male rats. The results also demonstrate that ocular acetylcholinesterase and butyrylcholinesterase activities differ between males and females, although this difference is not likely large enough to account for the observed gender difference.
本研究旨在调查梭曼蒸气对大鼠的缩瞳效力，以及先前报道的其他神经毒剂在缩瞳反应中的性别差异。本研究结果表明，梭曼蒸气的缩瞳效力明显低于其他神经毒剂，并且雌性大鼠对梭曼蒸气的敏感性是雄性大鼠的2.5至3.0倍。结果还表明，雄性和雌性大鼠的眼内乙酰胆碱酯酶和丁酰胆碱酯酶活性存在差异，尽管这种差异可能不足以解释观察到的性别差异。
