Zschocke Ina, Reich Christine, Zielke Andrea, Reitmeier Nadja, Reich Kristian
SCIderm Institute for Clinical Research, Hamburg, Germany.
J Dermatolog Treat. 2008;19(3):176-81. doi: 10.1080/09546630701593457.
To compare silica gel with acyclovir cream in the treatment of recurrent herpes labialis.
In this randomized, open-label, comparator-controlled trial, 74 patients with recurrent herpes labialis applied silica gel or acyclovir cream respectively over a period of 10 days. The treatment started within 24 hours of the first symptoms of a new recurrence. Patients rated five symptoms (tautness, tingling, itching, burning sensation, pain), lesion stage, efficacy, tolerability, and duration until the onset of improvement. Their willingness-to-pay was assessed. Physicians rated the severity of the herpes recurrence and efficacy.
There was no significant difference between silica gel and acyclovir cream in the overall patients' assessment. There is evidence that silica gel relieved all investigated symptoms earlier than acyclovir cream. The efficacy and tolerability of both medications were rated as good to very good.
Silica gel was as effective in the treatment of recurrent herpes labialis as acyclovir and equally well tolerated and tended to take effect more quickly. Therefore, silica gel could prove a useful alternative to topical acyclovir.
比较硅胶与阿昔洛韦乳膏治疗复发性唇疱疹的效果。
在这项随机、开放标签、对照试验中，74例复发性唇疱疹患者分别使用硅胶或阿昔洛韦乳膏，为期10天。治疗在新复发的首次症状出现后24小时内开始。患者对五种症状（紧绷感、刺痛感、瘙痒感、烧灼感、疼痛）、皮损阶段、疗效、耐受性以及改善开始前的持续时间进行评分。评估他们的支付意愿。医生对唇疱疹复发的严重程度和疗效进行评分。
在总体患者评估中，硅胶与阿昔洛韦乳膏之间无显著差异。有证据表明硅胶比阿昔洛韦乳膏更早缓解所有研究症状。两种药物的疗效和耐受性均被评为良好至非常好。
硅胶治疗复发性唇疱疹的效果与阿昔洛韦相当，耐受性相同，且起效更快。因此，硅胶可能是局部使用阿昔洛韦的一种有用替代药物。
