Acharya S, Barraclough J, Ibrahim M S, Oxby C, Jones S E, Parapia L, O'donovan P
Department of Obstetrics and Gynaecology, Bradford Royal infirmary, Bradford, UK.
J Obstet Gynaecol. 2008 Apr;28(3):310-4. doi: 10.1080/01443610802141910.
The prevalence of underlying bleeding disorders is common in women with menorrhagia. This was a prospective study to screen for the underlying bleeding disorders in women presenting with menorrhagia by using the PFA-100 and comparing the accuracy of the results with the complete haematological assays. A total of 62 women referred to gynaecology outpatients with a history of heavy, regular periods had blood collected for analysis by the PFA-100 and also a full coagulation profile including von Willebrand factor. PFA-100 analysis suggested platelet defects in 10 (16%) women. This included five (8%) identified with von Willebrand disease, two (3.2%) with storage pool disorders and three (4.8%) without any recognisable platelet or bleeding disorders after a full coagulation profile, including von Willebrand factor, was carried out. PFA-100 results had a sensitivity of 100% and specificity of 94.8% in our study. We conclude that PFA-100 is a quick and reliable method of screening for impaired haemostasis in patients with menorrhagia.
月经过多的女性中潜在出血性疾病的患病率较高。这是一项前瞻性研究，旨在通过使用血小板功能分析仪-100（PFA-100）筛查月经过多女性的潜在出血性疾病，并将结果的准确性与完整血液学检测进行比较。共有62名因月经过多且月经规律而转诊至妇科门诊的女性接受了血液采集，用于PFA-100分析以及包括血管性血友病因子在内的完整凝血指标检测。PFA-100分析提示10名（16%）女性存在血小板缺陷。其中包括5名（8%）确诊为血管性血友病的女性，2名（3.2%）存在血小板贮存池病的女性，以及3名（4.8%）在进行包括血管性血友病因子在内的完整凝血指标检测后未发现任何可识别的血小板或出血性疾病的女性。在我们的研究中，PFA-100结果的敏感性为100%，特异性为94.8%。我们得出结论，PFA-100是筛查月经过多患者止血功能受损的一种快速且可靠的方法。
