Hadj-Bouazza Amel, Teste Karine, Colombeau Ludovic, Chaleix Vincent, Zerrouki Rachida, Kraemer Michel, Sainte Catherine Odile
Laboratoire de Chimie des Substances Naturelles, Faculte des Sciences et Techniques Limoges, Universite de Limoges, France.
Nucleosides Nucleotides Nucleic Acids. 2008 May;27(5):439-48. doi: 10.1080/15257770802086872.
The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.
本文介绍了一种新型DNA交联抗肿瘤药物的合成及其生物活性。在体外对A431外阴表皮癌细胞系进行测试时，这种新型烷基化剂显著抑制了细胞增殖、迁移和侵袭。
