Koch H C, Burmeister W, Liappis N, Soetadji S, Wagner D, Langner B
Universitäts-Kinderklinik und Poliklinik Bonn.
Klin Padiatr. 1991 May-Jun;203(3):167-72. doi: 10.1055/s-2007-1025424.
In 73 healthy (group I) and 32 children and juveniles with insulin dependent diabetes mellitus (IDDM, group II) urinary albumin excretion is determined by radioimmunoassay (RIA). In both groups albumin excretion is observed in every urine sample when measured by RIA (mean +/- SD: group I: 7-19 h: 5.17 +/- 5.28 mg, 19-7 h: 3.86 +/- 4.00 mg, 24 h: 9.03 +/- 8.60 mg; group II: 7-19 h: 6.68 +/- 6.86 mg, 19-7 h: 3.46 +/- 2.82 mg, 24 h: 10.13 +/- 9.25 mg). No significant difference is detected between the values of the two groups. However in diabetic patients a significant difference is observed between diurnal and nocturnal urinary albumin excretion. Microalbuminuria is defined as an albumin excretion above 30 mg/d and is present in 6.9% of the values in group I and in 3.1% in group II. The physiological limits of microalbuminuria in children and juveniles compared to adults and several methods of urine sampling are discussed.
对73名健康儿童（第一组）和32名胰岛素依赖型糖尿病儿童及青少年（IDDM，第二组），采用放射免疫分析法（RIA）测定尿白蛋白排泄量。在两组中，通过RIA法检测每个尿样时均观察到白蛋白排泄（均值±标准差：第一组：7 - 19小时：5.17±5.28毫克，19 - 7小时：3.86±4.00毫克，24小时：9.03±8.60毫克；第二组：7 - 19小时：6.68±6.86毫克，19 - 7小时：3.46±2.82毫克，24小时：10.13±9.25毫克）。两组数值之间未检测到显著差异。然而，糖尿病患者日间和夜间尿白蛋白排泄量之间存在显著差异。微量白蛋白尿定义为白蛋白排泄量高于30毫克/天，在第一组中占比6.9%，在第二组中占比3.1%。文中讨论了儿童和青少年与成人相比微量白蛋白尿的生理限度以及几种尿液采样方法。
