[血小板衍生生长因子受体α和β在结直肠癌中的表达及临床意义]

[Expression and clinical significance of PDGFRalpha and PDGFRbeta in colorectal cancer].

作者信息

Zhu Hao-Tu, Han Jun, Ma Lin

机构信息

Department of Medical Oncology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, P. R. China.

出版信息

Ai Zheng. 2008 Jun;27(6):654-60.

PMID:18570744

Abstract

BACKGROUND & OBJECTIVE: Platelet-derived growth factor receptor-alpha (PDGFRalpha) and -beta (PDGFRbeta) play important roles in the invasion and metastasis of solid tumors. However, their correlations to colorectal cancer have seldom been reported. This study was to detect the expression of PDGFRalpha and PDGFRbeta in colorectal cancer, and investigate their clinical significance.

METHODS

The expression of PDGFRalpha and PDGFRbeta in 122 specimens of colorectal cancer and 17 specimens of normal colorectal tissues was detected by SABC immunohistochemistry. The correlations of their expression to the clinicopathologic characteristics and prognosis of the colorectal cancer patients were analyzed.

RESULTS

The high expression rates of PDGFRalpha and PDGFRbeta were 68.8% and 65.6% in colorectal cancer, but no high expression was found in normal colorectal tissues. PDGFRalpha expression was positively correlated to PDGFRbeta expression in colorectal cancer (r=0.416, P<0.001). The expression of PDGFRalpha was positively correlated to the stage of primary lesion, regional lymph node metastasis, distant metastasis and Dukes'stage. The high expression rate of PDGFRbeta was significantly higher in Dukes'C and D tumors than in Dukes'A and B tumors (73.8% vs. 56.1%, P=0.040). The 3-year overall and progression-free survival rates were significantly lower in the patients with high PDGFRalpha expression than in those with low PDGFRalpha expression (61.5% vs. 72.1%, 43.2% vs. 72.8%, P<0.05); the 3-year progression-free survival rate was significantly lower in PDGFRalpha-positive patients than in PDGFRalpha-negative patients (47.3% vs. 72.1%, P<0.05). On multivariate analysis, both PDGFRalpha and PDGFRbeta were not independent prognostic factors of colorectal cancer.

CONCLUSIONS

PDGFRalpha and PDGFRbeta are overexpressed in colorectal cancer, and are related with the progression of colorectal cancer. Both PDGFRalpha and PDGFRbeta are not independent prognostic factors of colorectal cancer.

摘要

背景与目的

血小板衍生生长因子受体α（PDGFRα）和β（PDGFRβ）在实体瘤的侵袭和转移中发挥重要作用。然而，它们与结直肠癌的相关性鲜有报道。本研究旨在检测结直肠癌中PDGFRα和PDGFRβ的表达，并探讨其临床意义。

方法

采用SABC免疫组织化学法检测122例结直肠癌标本及17例正常结直肠组织中PDGFRα和PDGFRβ的表达。分析其表达与结直肠癌患者临床病理特征及预后的相关性。

结果

结直肠癌中PDGFRα和PDGFRβ的高表达率分别为68.8%和65.6%，而正常结直肠组织中未发现高表达。结直肠癌中PDGFRα表达与PDGFRβ表达呈正相关（r=0.416，P<0.001）。PDGFRα表达与原发灶分期、区域淋巴结转移、远处转移及Dukes分期呈正相关。Dukes'C和D期肿瘤中PDGFRβ的高表达率显著高于Dukes'A和B期肿瘤（73.8%对56.1%，P=0.040）。PDGFRα高表达患者的3年总生存率和无进展生存率显著低于低表达患者（61.5%对72.1%，43.2%对72.8%，P<0.05）；PDGFRα阳性患者的3年无进展生存率显著低于PDGFRα阴性患者（47.3%对72.1%，P<0.05）。多因素分析显示，PDGFRα和PDGFRβ均不是结直肠癌的独立预后因素。