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A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release.剪接体中的构象重排为依赖Prp22的mRNA释放奠定了基础。
Mol Cell. 2008 Jun 20;30(6):743-54. doi: 10.1016/j.molcel.2008.05.003.
2
psiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation.psiCLIP 揭示了 DEAH -box 解旋酶在exon 连接前后的动态 RNA 结合。
Nat Commun. 2021 Mar 5;12(1):1488. doi: 10.1038/s41467-021-21745-9.
3
Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.前体mRNA剪接第二步过程中Prp8、Prp18、Slu7和U5小核仁核糖核酸之间的功能相互作用。
RNA. 2007 Sep;13(9):1437-44. doi: 10.1261/rna.572807. Epub 2007 Jul 12.
4
Interaction of the yeast DExH-box RNA helicase prp22p with the 3' splice site during the second step of nuclear pre-mRNA splicing.酵母DExH盒RNA解旋酶prp22p在核内前体mRNA剪接第二步过程中与3'剪接位点的相互作用。
Nucleic Acids Res. 2000 Mar 15;28(6):1313-21. doi: 10.1093/nar/28.6.1313.
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Cwc21p promotes the second step conformation of the spliceosome and modulates 3' splice site selection.Cwc21p促进剪接体的第二步构象并调节3'剪接位点的选择。
Nucleic Acids Res. 2015 Mar 31;43(6):3309-17. doi: 10.1093/nar/gkv159. Epub 2015 Mar 3.
6
Cryo-EM structure of the spliceosome immediately after branching.分支后剪接体的冷冻电镜结构
Nature. 2016 Sep 8;537(7619):197-201. doi: 10.1038/nature19316. Epub 2016 Jul 26.
7
Conformational dynamics of stem II of the U2 snRNA.U2小核核糖核酸茎II的构象动力学
RNA. 2016 Feb;22(2):225-36. doi: 10.1261/rna.052233.115. Epub 2015 Dec 2.
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Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing.酵母Prp2释放5'剪接位点和分支位点腺苷以催化前体mRNA剪接。
RNA. 2017 Dec;23(12):1770-1779. doi: 10.1261/rna.063115.117. Epub 2017 Sep 1.
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The spliceosome catalyzes debranching in competition with reverse of the first chemical reaction.剪接体催化分支脱离，与第一个化学反应的逆反应竞争。
RNA. 2013 Jul;19(7):971-81. doi: 10.1261/rna.038638.113. Epub 2013 May 16.
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A central role of Cwc25 in spliceosome dynamics during the catalytic phase of pre-mRNA splicing.Cwc25在mRNA前体剪接催化阶段的剪接体动力学中起核心作用。
RNA. 2017 Apr;23(4):546-556. doi: 10.1261/rna.059204.116. Epub 2017 Jan 5.
引用本文的文献
1
New mechanistic insights into Prp22-mediated exon ligation and mRNA release.对Prp22介导的外显子连接和mRNA释放的新机制见解。
Nucleic Acids Res. 2025 Aug 27;53(16). doi: 10.1093/nar/gkaf823.
2
Control of 3' splice site selection by the yeast splicing factor Fyv6.酵母剪接因子Fyv6对3'剪接位点选择的调控
Elife. 2024 Dec 17;13:RP100449. doi: 10.7554/eLife.100449.
3
Integration analysis of miRNA-mRNA pairs between two contrasting genotypes reveals the molecular mechanism of jujube (Ziziphus jujuba Mill.) response to high-temperature stress.整合分析两个不同基因型之间的 miRNA-mRNA 对，揭示了枣树（Ziziphus jujuba Mill.）对高温胁迫响应的分子机制。
BMC Plant Biol. 2024 Jun 27;24(1):612. doi: 10.1186/s12870-024-05304-0.
4
Control of 3' splice site selection by the yeast splicing factor Fyv6.酵母剪接因子Fyv6对3'剪接位点选择的调控
bioRxiv. 2024 Oct 21:2024.05.04.592262. doi: 10.1101/2024.05.04.592262.
5
Biochemical and genetic evidence supports Fyv6 as a second-step splicing factor in .生化和遗传证据支持 Fyv6 作为. 的第二步剪接因子。
RNA. 2023 Nov;29(11):1792-1802. doi: 10.1261/rna.079607.123. Epub 2023 Aug 25.
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Arresting Spliceosome Intermediates at Various Stages of the Splicing Pathway.在剪接途径的各个阶段捕获剪接体中间产物。
Methods Mol Biol. 2023;2666:193-211. doi: 10.1007/978-1-0716-3191-1_15.
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A clue to the catalytic activation of splicing.剪接催化激活的一个线索。
Nature. 2023 May;617(7962):680-681. doi: 10.1038/d41586-023-01528-6.
8
Structural basis of catalytic activation in human splicing.人类剪接中催化激活的结构基础。
Nature. 2023 May;617(7962):842-850. doi: 10.1038/s41586-023-06049-w. Epub 2023 May 10.
9
Biochemical and Genetic Evidence Supports Fyv6 as a Second-Step Splicing Factor in .生化和遗传证据支持Fyv6作为……中的第二步剪接因子。
bioRxiv. 2023 Jan 31:2023.01.30.526368. doi: 10.1101/2023.01.30.526368.
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Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes.剪接体组装和调控：来自高度简化剪接体分析的启示。
RNA. 2023 May;29(5):531-550. doi: 10.1261/rna.079273.122. Epub 2023 Feb 3.
本文引用的文献
1
Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly.ATP酶Prp5与分支区域-U2小核核糖核酸（snRNA）配对之间的竞争调节剪接体组装的保真度。
Mol Cell. 2007 Dec 14;28(5):838-49. doi: 10.1016/j.molcel.2007.09.022.
2
The long unwinding road of RNA helicases.RNA解旋酶漫长的曲折之路。
Mol Cell. 2007 Aug 3;27(3):339-52. doi: 10.1016/j.molcel.2007.07.014.
3
Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.前体mRNA剪接第二步过程中Prp8、Prp18、Slu7和U5小核仁核糖核酸之间的功能相互作用。
RNA. 2007 Sep;13(9):1437-44. doi: 10.1261/rna.572807. Epub 2007 Jul 12.
4
The Prp18 protein stabilizes the interaction of both exons with the U5 snRNA during the second step of pre-mRNA splicing.在mRNA前体剪接的第二步中，Prp18蛋白可稳定两个外显子与U5小核核糖核酸（snRNA）之间的相互作用。
Genes Dev. 2007 May 15;21(10):1204-16. doi: 10.1101/gad.1538207.
5
Inhibition of a spliceosome turnover pathway suppresses splicing defects.抑制剪接体周转途径可抑制剪接缺陷。
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13700-5. doi: 10.1073/pnas.0603188103. Epub 2006 Aug 31.
6
Remodeling of ribonucleoprotein complexes with DExH/D RNA helicases.利用DExH/D RNA解旋酶对核糖核蛋白复合物进行重塑。
Nucleic Acids Res. 2006;34(15):4181-8. doi: 10.1093/nar/gkl410. Epub 2006 Aug 25.
7
The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.外显子连接复合体的晶体结构揭示了它如何在信使核糖核酸（mRNA）上保持稳定的附着。
Cell. 2006 Aug 25;126(4):713-25. doi: 10.1016/j.cell.2006.08.006.
8
Exon ligation is proofread by the DExD/H-box ATPase Prp22p.外显子连接由DEAD/H盒ATP酶Prp22p进行校对。
Nat Struct Mol Biol. 2006 Jun;13(6):482-90. doi: 10.1038/nsmb1093. Epub 2006 May 7.
9
Mechanisms of helicases.解旋酶的作用机制。
J Biol Chem. 2006 Jul 7;281(27):18265-8. doi: 10.1074/jbc.R600008200. Epub 2006 May 2.
10
snRNAs as the catalysts of pre-mRNA splicing.小核仁RNA作为前体信使核糖核酸剪接的催化剂。
Curr Opin Chem Biol. 2005 Dec;9(6):603-8. doi: 10.1016/j.cbpa.2005.10.008. Epub 2005 Oct 20.
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