Krug Isabel, Treasure Janet, Anderluh Marija, Bellodi Laura, Cellini Elena, di Bernardo Milena, Granero Roser, Karwautz Andreas, Nacmias Benedetta, Penelo Eva, Ricca Valdo, Sorbi Sandro, Tchanturia Kate, Wagner Gudrun, Collier David, Fernández-Aranda Fernando
Department of Psychiatry, Bellvitge University Hospital, Barcelona and Ciber Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Spain.
Drug Alcohol Depend. 2008 Sep 1;97(1-2):169-79. doi: 10.1016/j.drugalcdep.2008.04.015. Epub 2008 Jun 20.
To assess the differences in comorbid lifetime and current substance use (tobacco, alcohol and drug use) between eating disorder (ED) patients and healthy controls in five different European countries.
A total of 1664 participants took part in the present study. ED cases (n=879) were referred to specialized ED units in five European countries. The ED cases were compared to a balanced control group of 785 healthy individuals.
Participants completed the Substance Use Subscale of the Cross Cultural (Environmental) Questionnaire (CCQ), a measure of lifetime tobacco, alcohol and drug use. In the control group, also the GHQ-28, the SCID-I interview and the EAT-26 were used.
ED patients had higher lifetime and current tobacco and general drug use. The only non-significant result was obtained for lifetime and current alcohol use. Significant differences across ED subdiagnoses and controls also emerged, with BN and AN-BP generally presenting the highest and AN-R and controls the lowest rates. The only exception was detected for alcohol use where EDNOS demonstrated the highest values. Only a few cultural differences between countries emerged.
With the exception of alcohol consumption, tobacco and drug use appear to be more prevalent in ED patients than healthy controls. The differential risk observed in patients with bulimic features might be related to differences in temperament or might be the result of increased sensitivity to reward.
评估五个不同欧洲国家饮食失调(ED)患者与健康对照者在共病终生及当前物质使用(烟草、酒精和药物使用)方面的差异。
共有1664名参与者参与了本研究。ED病例(n = 879)来自欧洲五个国家的专门ED科室。将ED病例与由785名健康个体组成的均衡对照组进行比较。
参与者完成了跨文化(环境)问卷(CCQ)的物质使用分量表,这是一种对终生烟草、酒精和药物使用情况的测量工具。在对照组中,还使用了一般健康问卷-28(GHQ-28)、精神障碍诊断与统计手册第一版(SCID-I)访谈以及进食障碍问卷-26(EAT-26)。
ED患者终生及当前的烟草和一般药物使用量更高。在终生及当前酒精使用方面,是唯一未得出显著结果的情况。ED亚诊断组与对照组之间也出现了显著差异,暴食症(BN)和神经性厌食症-暴食-清除型(AN-BP)的比率通常最高,而神经性厌食症-限制型(AN-R)和对照组的比率最低。唯一的例外是酒精使用情况,未特定指明的进食障碍(EDNOS)表现出最高值。国家之间仅出现了少数文化差异。
除酒精消费外,烟草和药物使用在ED患者中似乎比健康对照者更为普遍。在有贪食症特征的患者中观察到的不同风险可能与气质差异有关,或者可能是对奖励敏感度增加的结果。