Calero-Elvira Ana, Krug Isabel, Davis Kimberley, López Carolina, Fernández-Aranda Fernando, Treasure Janet
Department of Psychology, Autonomous University of Madrid, Madrid, Spain.
Eur Eat Disord Rev. 2009 Jul;17(4):243-59. doi: 10.1002/erv.936.
The aim of this study was to examine whether drug use (DU) is higher in people with eating disorders (EDs) compared to a healthy control group and to perform a meta-analysis on the literature related to DU in people with EDs.
We searched electronic databases (Medline, PsycINFO, Web of Science and CINAHL) and reviewed studies published from 1994 to August, 2007, in English, German or Spanish. A total of 16 papers fulfilled the inclusion criteria and were included.
The general meta-analysis revealed a negligible albeit significant effect size (0.119, p < .05). Risk was found to be higher in bulimia nervosa (BN, delta = 0.462, p = < .001), smaller in binge eating disorder (delta = 0.14, p < .05) and non-significant in anorexia nervosa (AN, delta = -.167, p = .070).
The differential risk observed in patients with BN might be related to differences in temperament or might be the result of reward sensitization.
本研究旨在探讨饮食失调（ED）患者与健康对照组相比药物使用（DU）情况是否更高，并对与ED患者DU相关的文献进行荟萃分析。
我们检索了电子数据库（Medline、PsycINFO、科学网和护理学与健康领域数据库），并回顾了1994年至2007年8月以英文、德文或西班牙文发表的研究。共有16篇论文符合纳入标准并被纳入。
总体荟萃分析显示效应量虽小但显著（0.119，p < .05）。发现神经性贪食症（BN）的风险更高（效应量差值 = 0.462，p < .001），暴饮暴食症的风险较小（效应量差值 = 0.14，p < .05），神经性厌食症（AN）的风险无显著差异（效应量差值 = -0.167，p = .070）。
BN患者中观察到的不同风险可能与气质差异有关，也可能是奖励敏感化的结果。
