Holtzer Roee, Goldin Yelena, Zimmerman Molly, Katz Mindy, Buschke Herman, Lipton Richard B
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA.
Arch Clin Neuropsychol. 2008 Sep;23(5):531-41. doi: 10.1016/j.acn.2008.05.004. Epub 2008 Jun 24.
The current study provided longitudinal robust norms for individuals age 70 years and older for several neuropsychological tests. We compared baseline neuropsychological test performance in three groups free of dementia at baseline: a robust normative sample free of dementia for at least two post-follow-up assessments, an incident dementia sample which developed new onset dementia during the follow-up and a lost to follow-up (LTF) sample. ANCOVAs showed that the robust sample performed better on all neuropsychological tests compared to the incident dementia and LTF samples. These findings support the argument that individuals in transition to developing dementia may reduce the mean, increase the variability and therefore underestimate cognitive performance in normal aging. We suggest that longitudinal robust norms may help mitigate the limitations inherent in cross-sectional normative samples.
本研究为70岁及以上个体的多项神经心理学测试提供了纵向稳健常模。我们比较了三组在基线时无痴呆症的个体的基线神经心理学测试表现:一个在至少两次随访评估中无痴呆症的稳健常模样本、一个在随访期间出现新发痴呆症的新发痴呆症样本以及一个失访(LTF)样本。协方差分析表明,与新发痴呆症样本和失访样本相比,稳健样本在所有神经心理学测试中的表现更好。这些发现支持了这样一种观点,即处于向痴呆症发展过渡阶段的个体可能会降低平均值、增加变异性,从而低估正常衰老过程中的认知表现。我们建议纵向稳健常模可能有助于减轻横断面常模样本中固有的局限性。