磷脂酰肌醇-4,5-二磷酸（PIP2）是离子通道功能所必需的辅助因子：其作用方式及原因是什么？
PIP2 is a necessary cofactor for ion channel function: how and why?
作者信息
Suh Byung-Chang, Hille Bertil
机构信息
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195, USA.
出版信息
Annu Rev Biophys. 2008;37:175-95. doi: 10.1146/annurev.biophys.37.032807.125859.
Abstract
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.
摘要
磷脂酰肌醇-4,5-二磷酸（PIP2）是质膜内小叶中的一种少数磷脂。许多质膜离子通道和离子转运体需要PIP2才能发挥功能，并且可以被耗尽PIP2的信号通路关闭。本文综述了离子通道对磷酸肌醇的依赖性，并探讨了PIP2及其类似物调节离子通道活性的可能机制。
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