Hara Megumi, Sakamoto Tatsuhiko, Tanaka Keitaro
Department of Preventive Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.
Vaccine. 2008 Nov 25;26(50):6477-80. doi: 10.1016/j.vaccine.2008.06.035. Epub 2008 Jun 23.
To examine the effectiveness of influenza vaccine among community-dwelling elderly (65-79 years old), we conducted a population-based cohort study during the 2003--2004 influenza season. A total of 4787 elderly individuals were interviewed regarding acute febrile illness, hospital visits, hospitalization and death by telephone every month. The vaccination status and physician-diagnosed clinical influenza (hereinafter referred as clinical influenza) were determined based on data obtained from the city office and hospitals, respectively. After adjusting for confounders, the odds ratio (OR) of vaccination for influenza-like illness (ILI) with high-fever, which was defined as an acute febrile illness (> or =38.5 degrees C) during the epidemic period, was 0.38 (95% confidence interval [CI], 0.17-0.85) and the OR for clinical influenza was 0.76 (95%CI, 0.28-2.06). Due to the inadequate sample size, ORs for preventing hospitalization for influenza or pneumonia (OR, 0.37; 95%CI, 0.09-1.47) and death (OR, 3.68; 95%CI, 0.75-18.12) were not conclusive. These results suggested that vaccination was therefore effective for elderly persons living in the community.
为研究流感疫苗对社区居住老年人（65 - 79岁）的有效性，我们在2003 - 2004年流感季节开展了一项基于人群的队列研究。每月通过电话对总共4787名老年人进行急性发热性疾病、就诊、住院和死亡情况的访谈。疫苗接种状况和医生诊断的临床流感（以下简称临床流感）分别根据从市政办公室和医院获取的数据确定。在对混杂因素进行调整后，针对流感样疾病（ILI）伴高热（定义为流行期间急性发热性疾病（≥38.5摄氏度））的疫苗接种优势比（OR）为0.38（95%置信区间[CI]，0.17 - 0.85），临床流感的OR为0.76（95%CI，0.28 - 2.06）。由于样本量不足，预防流感或肺炎住院的OR（OR，0.37；95%CI，0.09 - 1.47）和死亡的OR（OR，3.68；95%CI，0.75 - 18.12）并不确凿。这些结果表明，疫苗接种对社区居住的老年人是有效的。
