多发性硬化症患者及其一级亲属中的自身免疫性疾病：丹麦的一项全国性队列研究。

Autoimmune diseases in patients with multiple sclerosis and their first-degree relatives: a nationwide cohort study in Denmark.

作者信息

Nielsen N M, Frisch M, Rostgaard K, Wohlfahrt J, Hjalgrim H, Koch-Henriksen N, Melbye M, Westergaard T

机构信息

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

出版信息

Mult Scler. 2008 Jul;14(6):823-9. doi: 10.1177/1352458508088936. Epub 2008 Jun 23.

DOI:10.1177/1352458508088936

PMID:18573841

Abstract

BACKGROUND

Multiple sclerosis (MS) and other autoimmune diseases might cluster. Our aim was to estimate the relative risk (RR) of other autoimmune diseases among MS patients and their first-degree relatives in a population-based cohort study.

METHODS

Using the Danish Multiple Sclerosis Register, the Danish Hospital Discharge Register, and the Danish Civil Registration System, we estimated RRs for 42 different autoimmune diseases in a population-based cohort of 12 403 MS patients and 20 798 of their first-degree relatives. Ratios of observed to expected numbers of autoimmune diseases, based on national sex-, age-, and period-specific incidence rates, served as measures of the RRs.

RESULTS

Compared with the general population, MS patients were at an increased risk of developing ulcerative colitis (RR = 2.0 (95% confidence interval (CI): 1.4-2.8), n = 29) and pemphigoid (RR = 15.4 (CI: 8.7-27.1), n = 12) but at reduced risk of rheumatoid arthritis (RR = 0.5 (CI: 0.4-0.8), n = 28) and temporal arteritis (RR = 0.5 (CI: 0.3-0.97), n = 11). First-degree relatives of MS patients were at increased risks of Crohn's disease (RR = 1.4 (CI: 1.04-1.9), n = 44), ulcerative colitis (RR = 1.3 (CI: 0.99-1.7), n = 51), Addison's disease (RR = 3.4 (CI: 1.3-9.0), n = 4), and polyarteritis nodosa (RR = 3.7 (CI: 1.4-10.0), n = 4).

PATIENTS

with MS and their first-degree relatives seem to be at an increased risk of acquiring certain other autoimmune diseases.

摘要

背景

多发性硬化症（MS）和其他自身免疫性疾病可能会聚集发生。我们的目的是在一项基于人群的队列研究中，估算MS患者及其一级亲属患其他自身免疫性疾病的相对风险（RR）。

方法

利用丹麦多发性硬化症登记册、丹麦医院出院登记册和丹麦民事登记系统，我们在一个基于人群的队列中估算了12403例MS患者及其20798名一级亲属患42种不同自身免疫性疾病的RR。基于全国按性别、年龄和时期划分的发病率，自身免疫性疾病的观察数与预期数之比作为RR的衡量指标。

结果

与普通人群相比，MS患者患溃疡性结肠炎（RR = 2.0（95%置信区间（CI）：1.4 - 2.8），n = 29）和类天疱疮（RR = 15.4（CI：8.7 - 27.1），n = 12）的风险增加，但患类风湿性关节炎（RR = 0.5（CI：0.4 - 0.8），n = 28）和颞动脉炎（RR = 0.5（CI：0.3 - 0.97），n = 11）的风险降低。MS患者的一级亲属患克罗恩病（RR = 1.4（CI：1.04 - 1.9），n = 44）、溃疡性结肠炎（RR = 1.3（CI：0.99 - 1.7），n = 51）、艾迪生病（RR = 3.4（CI：1.3 - 9.0），n = 4）和结节性多动脉炎（RR = 3.7（CI：1.4 - 10.0），n = 4）的风险增加。