Chisholm-Burns Marie A, Kwong W Jaqueline, Mulloy Laura L, Spivey Christina A
Department of Pharmacy Practice and Science, The University of Arizona College of Pharmacy (UACP), Tucson, AZ 85721, USA.
Am J Health Syst Pharm. 2008 Jul 1;65(13):1242-7. doi: 10.2146/ajhp070630.
Relationships between adherence to immunosuppressant therapy and adult renal transplant recipients' age, time posttransplant, race, and sex were evaluated to identify factors that predict nonadherence.
Pharmacy refill data were used to measure adherence. In a primary analysis, stepwise regression was used to assess the relationship between independent variables (age, sex, time posttransplant, and race) and adherence. In a secondary analysis to provide categorical summaries, stepwise regression was used to assess the relationship between independent variables (age quartiles, sex, time posttransplant quartiles, and race) and adherence.
In the primary analysis, age and time posttransplant were significant predictors of adherence rate (p < 0.05), with adherence rate decreasing as age and time posttransplant increased. In the secondary analysis, age quartile 4 (>or=60 years) and time posttransplant quartile 1 (<or=4 years) were significant predictors of adherence (p < 0.01), with adherence rates lower among age quartile 4 and higher among posttransplant quartile 1.
In patients who had received renal transplants, the rate of adherence to immunosuppressant therapy decreased as patient age and time since transplantation increased.
评估免疫抑制剂治疗依从性与成人肾移植受者的年龄、移植后时间、种族和性别之间的关系，以确定预测不依从性的因素。
使用药房再填充数据来衡量依从性。在初步分析中，采用逐步回归来评估自变量（年龄、性别、移植后时间和种族）与依从性之间的关系。在提供分类汇总的二次分析中，采用逐步回归来评估自变量（年龄四分位数、性别、移植后时间四分位数和种族）与依从性之间的关系。
在初步分析中，年龄和移植后时间是依从率的显著预测因素（p<0.05），随着年龄和移植后时间的增加，依从率降低。在二次分析中，年龄四分位数4（≥60岁）和移植后时间四分位数1（≤4年）是依从性的显著预测因素（p<0.01），年龄四分位数4的依从率较低，移植后四分位数1的依从率较高。
在接受肾移植的患者中，免疫抑制剂治疗的依从率随着患者年龄和移植后时间的增加而降低。
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