Romeike B F M, Joellenbeck B, Stein H, Loddenkemper C, Hummel M, Firsching R, Mawrin C
Abteilung für Neuropathologie, Friedrich-Schiller-Universität, Jena, Germany.
Acta Neurochir (Wien). 2008 Aug;150(8):833-6. doi: 10.1007/s00701-008-1585-y. Epub 2008 Jun 27.
Only single examples of lymphoma associated with pituitary adenoma have been reported. In our patient, a precursor T-lymphoblastic lymphoma developed within a recurrent pituitary adenoma 17 years after the first resection. Histomorphologically, lymphoma and adenoma components were tightly admixed. The features harbour remarkable similarity to the previous report by Kuhn et al.. In both patients the lymphomas were composed of T-cells, there was no evidence of further sites involved, and both adenomas expressed follicle-stimulating hormone. The hormone may have posed a proliferative and transforming effect on lymphatic cells and could have played a crucial role in "lymphomagenesis" as an exceptional phenomenon.
仅报道过与垂体腺瘤相关的淋巴瘤的个别病例。在我们的患者中，首次切除垂体腺瘤17年后，复发性垂体腺瘤内发生了前驱T淋巴母细胞淋巴瘤。组织形态学上，淋巴瘤和腺瘤成分紧密混合。这些特征与库恩等人之前的报告有显著相似之处。在这两名患者中，淋巴瘤均由T细胞组成，没有其他部位受累的证据，且两种腺瘤均表达促卵泡激素。该激素可能对淋巴细胞产生了增殖和转化作用，并可能作为一种特殊现象在“淋巴瘤发生”中起关键作用。
