Schillaci Orazio, Danieli Roberta, Padovano Federico, Testa Angelo, Simonetti Giovanni
Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiation Therapy, University Hospital Tor Vergata, Rome, Italy.
Int J Mol Med. 2008 Jul;22(1):3-7.
Atherosclerosis is a systemic disease of the vessel wall that mainly affects medium- and large-sized arteries, and accounts for 50% of all deaths in western countries. Imaging of atheromatous plaques has traditionally centered on assessing the degree of luminal narrowing. More recently it has become clear that it is of the utmost importance to identify the vulnerable atherosclerotic plaques responsible for the majority of life-threatening syndromes. Molecular imaging using nuclear medicine techniques such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET), has the potential to characterize the activity of atheromas. In the present review we summarize the results of radionuclide imaging in the detection of vulnerable atherosclerotic lesions.
动脉粥样硬化是一种主要影响中、大动脉的血管壁系统性疾病，在西方国家占所有死亡人数的50%。传统上，动脉粥样硬化斑块的成像主要集中于评估管腔狭窄程度。最近，人们清楚地认识到，识别导致大多数危及生命综合征的易损动脉粥样硬化斑块至关重要。使用单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）等核医学技术的分子成像，有潜力对动脉粥样硬化的活性进行表征。在本综述中，我们总结了放射性核素成像在检测易损动脉粥样硬化病变方面的结果。
