Melick M R, Karim M N, Linden J C, Dale B E, Mihaltz P
Department of Agricultural and Chemical Engineering, Colorado State University, fort Collins, Colorado 80523.
Biotechnol Bioeng. 1987 Feb;29(3):370-82. doi: 10.1002/bit.260290314.
A mathematical model which describes ethanol production in a packed bed fermenter containing. Zymomonas mobilis entrapped in small spheres of calcium alginate within a packed bed fermenter has been developed. The equations combine simultaneous diffusion and reaction as well as a complex flow pattern to calculate glucose and ethanol profiles in the column type reactor. As part of the study, diffusivity values for glucose and ethanol in cell-loaded calcium alginate were determined. Also a freecell kinetic expression for Z. mobilis at 33 degrees C and ph 6.0 was developed. Comparison of the model with actual experimental results were made showing average deviations of ca. 30-40%.