Foresti M, Guidali A, Susanna P
Istituto di Radiodiagnostica, Ospedali Riuniti, Bergamo.
Radiol Med. 1991 Jun;81(6):803-7.
In 500 consecutive patients, aged 11-82 years, who underwent MR imaging of the brain for a variety of conditions not related to pathologic processes of the sellar or juxtasellar regions, the authors detected primary totally empty sella in 28/248 males (11.3%) and in 34/252 females (13.5%). Primary partially empty sella was found in 40/248 males (16.1%) and in 38/252 females (15.1%). A progressive increase in the incidence of the signs of primary empty sella was observed with aging, the increase being more conspicuous in the 5th decade of life in females (37.5%) and in the 6th decade in males (40%). On the whole, signs of primary empty sella were detected in 140/500 cases (38%)--namely, in 9.6% of the subjects under 40 and in 39.9% of those above 40. The incidence of primary empty sella, unrelated to any other clinical condition, seems to support its inclusion into paraphysiologic variants. On the basis of the data reported in literature, the authors consider the factors possibly playing a role in this condition. They seem to be: insufficiency or absence of diaphragma sellae, CSF pressure, and pituitary involution related to aging.
在500例年龄在11至82岁之间、因各种与鞍区或鞍旁区域病理过程无关的病症而接受脑部磁共振成像检查的连续患者中，作者在248名男性中的28名（11.3%）和252名女性中的34名（13.5%）检测到原发性完全空蝶鞍。在248名男性中的40名（16.1%）和252名女性中的38名（15.1%）发现原发性部分空蝶鞍。随着年龄增长，原发性空蝶鞍体征的发生率逐渐增加，这种增加在女性的第5个十年（37.5%）和男性的第6个十年（40%）更为明显。总体而言，在500例病例中的140例（38%）检测到原发性空蝶鞍体征，即40岁以下受试者中的9.6%和40岁以上受试者中的39.9%。与任何其他临床状况无关的原发性空蝶鞍发生率似乎支持将其纳入旁生理性变异。根据文献报道的数据，作者考虑了可能在这种情况中起作用的因素。它们似乎是：鞍膈不足或缺失、脑脊液压力以及与衰老相关的垂体 involution。 （注：involution这个词在医学语境中可能有不同含义，这里直接保留英文，未准确翻译，因为不清楚具体所指含义）
