Ruggiero R, Procaccini E, Gili S, Cremone C, Docimo G, Iovino F, Docimo L, Sparavigna L, Gubitosi A, Parmeggiani D, Avenia N
General and Specialistic Surgery, Second University of Naples, Naples, Italy.
Minerva Chir. 2008 Jun;63(3):249-54.
Axillary lymphadenectomy remains an integral part of breast cancer treatment, yet seroma formation occurs in 15-85% of cases. Among the methods employed to reduce seroma magnitude and duration, fibrin glue has been proposed in numerous studies with controversial
Sixty patients underwent quadrantectomy or mastectomy with level I/II axillary lymphadenectomy; a suction drain was fitted in all patients. Fibrin glue spray was applied to the axillary fossa in 30 patients; the other 30 patients were treated conventionally. Suction drainage was removed between postoperative days III and IV. Seroma magnitude and duration were significantly reduced (P=0.004 and 0.02, respectively), and there were fewer evacuative punctures, in patients receiving fibrin glue compared with the conventional treatment group. The authors conclude that the use of fibrin glue does not always prevent seroma formation, but does reduce seroma magnitude, duration and necessary evacuative punctures.
腋窝淋巴结清扫术仍是乳腺癌治疗的一个重要组成部分，但血清肿形成的发生率在15%至85%之间。在用于减少血清肿大小和持续时间的方法中，众多研究提出了纤维蛋白胶，但结果存在争议。
60例患者接受了象限切除术或乳房切除术及I/II级腋窝淋巴结清扫术；所有患者均放置了负压引流管。30例患者在腋窝窝内喷洒纤维蛋白胶；另外30例患者采用传统治疗。术后第III天至第IV天拔除负压引流管。与传统治疗组相比，接受纤维蛋白胶治疗的患者血清肿大小和持续时间显著降低（分别为P = 0.004和0.02），且抽吸引流穿刺次数更少。作者得出结论，使用纤维蛋白胶并不总是能预防血清肿形成，但确实能减少血清肿大小、持续时间和必要的抽吸引流穿刺次数。
