Popov M Iu
Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(6):28-33.
The aim of the article was to study efficacy and safety of nifedipine in the correction of extrapyramidal side-effects emerged during conventional neuroleptics therapy. Fifty-one patients diagnosed with paranoid schizophrenia received haloperidol in combination with nifedipine (25 patients) or haloperidol only (26 patients) during 26 weeks. Dynamics of psychopathological symptoms and extrapyramidal disorders were measured with PANSS, CGI, BARS, SARS and AIMS. Patients receiving haloperidol in combination with nifedipine had the lower AIMS scores indicating appearances of dyskinesia and less marked (on the trend to statistical significance) SARS scores measuring parkinsonian symptoms as compared to patients receiving monotherapy with haloperidol. The administration of nifedipine in combination with haloperidol did not reduce the therapeutic efficacy of the latter and did not lead to the increase of side-effects. The data obtained suggest that nifedipine may be used as a perspective corrector of extrapyramidal disorders caused by classical neuroleptics.
本文旨在研究硝苯地平对传统抗精神病药物治疗过程中出现的锥体外系副作用的疗效和安全性。51例被诊断为偏执型精神分裂症的患者在26周内接受了氟哌啶醇联合硝苯地平治疗（25例）或仅接受氟哌啶醇治疗（26例）。采用阳性和阴性症状量表（PANSS）、临床总体印象量表（CGI）、巴恩斯不自主运动评定量表（BARS）、标准化抗精神病药物副作用评定量表（SARS）和异常不自主运动量表（AIMS）来测量精神病理症状和锥体外系障碍的动态变化。与仅接受氟哌啶醇单一疗法的患者相比，接受氟哌啶醇联合硝苯地平治疗的患者的AIMS评分较低，表明运动障碍的出现较少，且测量帕金森症状的SARS评分（有统计学意义的趋势）较低。硝苯地平与氟哌啶醇联合使用不会降低后者的治疗效果，也不会导致副作用增加。所获得的数据表明，硝苯地平可作为经典抗精神病药物引起的锥体外系障碍的一种有前景的校正剂。
