Tarasova S V, Amelin A V, Skoromets A A
Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(6):43-6.
Efficacy of antidepressants fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache has been studied. Amitriptyline had the highest effect in dosage 50 mg daily but was not well tolerated by patients that resulted in that only 50% of them finished the study. Fluvoxamine had high efficacy and good tolerability in the treatment of chronic daily headache and medication overuse headache. Small dosages of amitriptyline and fluvoxamine potentiated the analgesic effect of transcranial electrostimulation of the brain. The combination of antidepressants with transcranial electrostimulation of the brain alleviated the negative effect of the withdrawal of overused analgesics and may be recommended for out-patient use.
已对抗抑郁药氟伏沙明、阿米替林及经颅电刺激治疗慢性每日头痛的疗效进行了研究。阿米替林每日剂量50毫克时效果最佳，但患者耐受性不佳，导致仅有50%的患者完成了研究。氟伏沙明在治疗慢性每日头痛及药物过度使用性头痛方面疗效显著且耐受性良好。小剂量的阿米替林和氟伏沙明可增强经颅电刺激的镇痛效果。抗抑郁药与经颅电刺激相结合可减轻停用过度使用的镇痛药所产生的负面影响，可推荐用于门诊治疗。
